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dc.contributor.authorXie, Mingchaoen_US
dc.contributor.authorHong, Chiboen_US
dc.contributor.authorZhang, Boen_US
dc.contributor.authorLowdon, Rebeccaen_US
dc.contributor.authorXing, Xiaoyunen_US
dc.contributor.authorLi, Daofengen_US
dc.contributor.authorZhou, Xinen_US
dc.contributor.authorLee, Hyung Jooen_US
dc.contributor.authorMaire, Cecile L.en_US
dc.contributor.authorLigon, Keith L.en_US
dc.contributor.authorGascard, Philippeen_US
dc.contributor.authorSigaroudinia, Mahvashen_US
dc.contributor.authorTlsty, Thea D.en_US
dc.contributor.authorKadlecek, Theresaen_US
dc.contributor.authorWeiss, Arthuren_US
dc.contributor.authorO’Geen, Henrietteen_US
dc.contributor.authorFarnham, Peggy J.en_US
dc.contributor.authorMadden, Pamela A.F.en_US
dc.contributor.authorMungall, Andrew J.en_US
dc.contributor.authorTam, Angelaen_US
dc.contributor.authorKamoh, Baljiten_US
dc.contributor.authorCho, Stephanieen_US
dc.contributor.authorMoore, Richarden_US
dc.contributor.authorHirst, Martinen_US
dc.contributor.authorMarra, Marco A.en_US
dc.contributor.authorCostello, Joseph F.en_US
dc.contributor.authorWang, Tingen_US
dc.date.accessioned2014-03-11T13:27:49Z
dc.date.issued2013en_US
dc.identifier.citationXie, M., C. Hong, B. Zhang, R. Lowdon, X. Xing, D. Li, X. Zhou, et al. 2013. “DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.” Nature genetics 45 (7): 10.1038/ng.2649. doi:10.1038/ng.2649. http://dx.doi.org/10.1038/ng.2649.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879711
dc.description.abstractIntroduction: Transposable element (TE) derived sequences comprise half of our genome and DNA methylome, and are presumed densely methylated and inactive. Examination of the genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues revealed unexpected tissue-specific and subfamily-specific hypomethylation signatures. Genes proximal to tissue-specific hypomethylated TE sequences were enriched for functions important for the tissue type and their expression correlated strongly with hypomethylation of the TEs. When hypomethylated, these TE sequences gained tissue-specific enhancer marks including H3K4me1 and occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays. Many such TEs also harbored binding sites for transcription factors that are important for tissue-specific functions and exhibited evidence for evolutionary selection. These data suggest that sequences derived from TEs may be responsible for wiring tissue type-specific regulatory networks, and have acquired tissue-specific epigenetic regulation.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.2649en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695047/pdf/en
dash.licenseLAAen_US
dc.titleDNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscapeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorLigon, Keith L.en_US
dc.date.available2014-03-11T13:27:49Z
dc.identifier.doi10.1038/ng.2649*
dash.authorsorderedfalse
dash.contributor.affiliatedLigon, Keith


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