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dc.contributor.authorCampa, Danieleen_US
dc.contributor.authorBarrdahl, Myrtoen_US
dc.contributor.authorTsilidis, Konstantinos K.en_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorDiver, W. Ryanen_US
dc.contributor.authorSiddiq, Afshanen_US
dc.contributor.authorChanock, Stephenen_US
dc.contributor.authorHoover, Robert N.en_US
dc.contributor.authorZiegler, Regina G.en_US
dc.contributor.authorBerg, Christine D.en_US
dc.contributor.authorBuys, Saundra S.en_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorHenderson, Brian E.en_US
dc.contributor.authorSchumacher, Fredrick R.en_US
dc.contributor.authorLe Marchand, Loïcen_US
dc.contributor.authorFlesch-Janys, Dieteren_US
dc.contributor.authorLindström, Saraen_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorHankinson, Susan E.en_US
dc.contributor.authorWillett, Walter C.en_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorCox, David G.en_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorTjønneland, Anneen_US
dc.contributor.authorDossus, Laureen_US
dc.contributor.authorTrichopoulos, Dimitriosen_US
dc.contributor.authorPanico, Salvatoreen_US
dc.contributor.authorvan Gils, Carla H.en_US
dc.contributor.authorWeiderpass, Elisabeteen_US
dc.contributor.authorBarricarte, Aurelioen_US
dc.contributor.authorSund, Malinen_US
dc.contributor.authorGaudet, Mia M.en_US
dc.contributor.authorGiles, Grahamen_US
dc.contributor.authorSouthey, Melissaen_US
dc.contributor.authorBaglietto, Lauraen_US
dc.contributor.authorChang-Claude, Jennyen_US
dc.contributor.authorKaaks, Rudolfen_US
dc.contributor.authorCanzian, Federicoen_US
dc.date.accessioned2014-03-11T13:52:16Z
dc.date.issued2014en_US
dc.identifier.citationCampa, D., M. Barrdahl, K. K. Tsilidis, G. Severi, W. R. Diver, A. Siddiq, S. Chanock, et al. 2014. “A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer.” PLoS ONE 9 (2): e85955. doi:10.1371/journal.pone.0085955. http://dx.doi.org/10.1371/journal.pone.0085955.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879756
dc.description.abstractApproximately 15–30% of all breast cancer tumors are estrogen receptor negative (ER−). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants identified for numerous cancer types, only seven loci have been unambiguously identified for ER-negative breast cancer. With the aim of identifying new susceptibility SNPs for this disease we performed a pleiotropic genome-wide association study (GWAS). We selected 3079 SNPs associated with a human complex trait or disease at genome-wide significance level (P<5×10−8) to perform a secondary analysis of an ER-negative GWAS from the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), including 1998 cases and 2305 controls from prospective studies. We then tested the top ten associations (i.e. with the lowest P-values) using three additional populations with a total sample size of 3509 ER+ cases, 2543 ER− cases and 7031 healthy controls. None of the 3079 selected variants in the BPC3 ER-GWAS were significant at the adjusted threshold. 186 variants were associated with ER− breast cancer risk at a conventional threshold of P<0.05, with P-values ranging from 0.049 to 2.3×10−4. None of the variants reached statistical significance in the replication phase. In conclusion, this study did not identify any novel susceptibility loci for ER-breast cancer using a “pleiotropic approach”.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0085955en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921107/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectGeneticsen
dc.subjectHuman Geneticsen
dc.subjectGenetic Association Studiesen
dc.subjectGenome-Wide Association Studiesen
dc.subjectPopulation Geneticsen
dc.subjectGenetic Polymorphismen
dc.subjectCancer Geneticsen
dc.subjectPopulation Biologyen
dc.subjectEpidemiologyen
dc.subjectGenetic Epidemiologyen
dc.subjectMedicineen
dc.subjectCancer Epidemiologyen
dc.subjectObstetrics and Gynecologyen
dc.subjectBreast Canceren
dc.subjectOncologyen
dc.subjectCancers and Neoplasmsen
dc.subjectBreast Tumorsen
dc.titleA Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Canceren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHunter, David J.en_US
dc.date.available2014-03-11T13:52:16Z
dc.identifier.doi10.1371/journal.pone.0085955*
dash.authorsorderedfalse
dash.contributor.affiliatedTrichopoulos, Dimitrios
dash.contributor.affiliatedKraft, Phillip
dash.contributor.affiliatedWillett, Walter
dash.contributor.affiliatedHunter, David
dash.contributor.affiliatedHankinson, Susan


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