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dc.contributor.authorKesselheim, Aaron S.en_US
dc.contributor.authorXu, Shuaien_US
dc.contributor.authorAvorn, Jerryen_US
dc.date.accessioned2014-03-11T13:52:18Z
dc.date.issued2014en_US
dc.identifier.citationKesselheim, Aaron S., Shuai Xu, and Jerry Avorn. 2014. “Clinicians’ Contributions to the Development of Coronary Artery Stents: A Qualitative Study of Transformative Device Innovation.” PLoS ONE 9 (2): e88664. doi:10.1371/journal.pone.0088664. http://dx.doi.org/10.1371/journal.pone.0088664.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879760
dc.description.abstractBackground: Medical device innovation remains poorly understood, and policymakers disagree over how to incentivize early development. We sought to elucidate the components of transformative health care innovation by conducting an in-depth case study of development of a key medical device: coronary artery stents. Methods and Findings: We conducted semi-structured interviews with the innovators whose work contributed to the development of coronary artery stents who we identified based on a review of the regulatory, patent, and medical literature. Semi-structured interviews with each participant covered the interviewee’s personal involvement in coronary artery stent development, the roles of institutions and other individuals in the development process, the interplay of funding and intellectual property in the interviewee’s contribution, and finally reflections on lessons arising from the experience. Transcripts were analyzed using standard coding techniques and the constant comparative method of qualitative data analysis. Conclusions: We found that the first coronary artery stents emerged from three teams: Julio Palmaz and Richard Schatz, Cesare Gianturco and Gary Roubin, and Ulrich Sigwart. First, these individual physician-inventors saw the need for coronary artery stents in their clinical practice. In response, they developed prototypes with the support of academic medical centers leading to early validation studies. Larger companies entered afterwards with engineering support. Patents became paramount once the technology diffused. The case of coronary stents suggests that innovation policy should focus on supporting early physician-inventors at academic centers.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0088664en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922977/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectBiotechnologyen
dc.subjectBioengineeringen
dc.subjectMedical Devicesen
dc.subjectEngineeringen
dc.subjectMedicineen
dc.subjectCardiovascularen
dc.subjectCoronary Artery Diseaseen
dc.subjectDrugs and Devicesen
dc.subjectNon-Clinical Medicineen
dc.subjectHistory of Medicineen
dc.subjectScience Policyen
dc.subjectTechnology Developmenten
dc.titleClinicians’ Contributions to the Development of Coronary Artery Stents: A Qualitative Study of Transformative Device Innovationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorKesselheim, Aaron S.en_US
dc.date.available2014-03-11T13:52:18Z
dc.identifier.doi10.1371/journal.pone.0088664*
dash.contributor.affiliatedXu, Shuai
dash.contributor.affiliatedAvorn, Jerome
dash.contributor.affiliatedKesselheim, Aaron


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