Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma

 
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Savage, Sharon A.
Mirabello, Lisa
Wang, Zhaoming
Gastier-Foster, Julie M.
Gorlick, Richard
Khanna, Chand
Flanagan, Adrienne M.
Tirabosco, Roberto
Andrulis, Irene L.
Wunder, Jay S.
Gokgoz, Nalan
Patiño-Garcia, Ana
Sierrasesúmaga, Luis
Lecanda, Fernando
Kurucu, Nilgün
Ilhan, Inci Ergurhan
Sari, Neriman
Serra, Massimo
Hattinger, Claudia
Picci, Piero
Spector, Logan
Barkauskas, Donald A.
Marina, Neyssa
de Toledo, Silvia Regina Caminada
Petrilli, Antonio S.
Amary, Maria Fernanda
Halai, Dina
Thomas, David M.
Meltzer, Paul S.
Jacobs, Kevin
Chung, Charles C.
Berndt, Sonja I.
Purdue, Mark P.
Caporaso, Neil E.
Tucker, Margaret
Rothman, Nathaniel
Landi, Maria Teresa
Silverman, Debra T.
Malats, Nuria
Kogevinas, Manolis
Wacholder, Sholom
Troisi, Rebecca
Helman, Lee
Fraumeni, Joseph F.
Yeager, Meredith
Hoover, Robert N.
Chanock, Stephen J.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ng.2645
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Savage, S. A., L. Mirabello, Z. Wang, J. M. Gastier-Foster, R. Gorlick, C. Khanna, A. M. Flanagan, et al. 2013. “Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma.” Nature genetics 45 (7): 799-803. doi:10.1038/ng.2645. http://dx.doi.org/10.1038/ng.2645.
Abstract
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10-9), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10-8 and 2.9 ×10-7). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910497/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879782

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