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dc.contributor.authorSavage, Sharon A.en_US
dc.contributor.authorMirabello, Lisaen_US
dc.contributor.authorWang, Zhaomingen_US
dc.contributor.authorGastier-Foster, Julie M.en_US
dc.contributor.authorGorlick, Richarden_US
dc.contributor.authorKhanna, Chanden_US
dc.contributor.authorFlanagan, Adrienne M.en_US
dc.contributor.authorTirabosco, Robertoen_US
dc.contributor.authorAndrulis, Irene L.en_US
dc.contributor.authorWunder, Jay S.en_US
dc.contributor.authorGokgoz, Nalanen_US
dc.contributor.authorPatiño-Garcia, Anaen_US
dc.contributor.authorSierrasesúmaga, Luisen_US
dc.contributor.authorLecanda, Fernandoen_US
dc.contributor.authorKurucu, Nilgünen_US
dc.contributor.authorIlhan, Inci Ergurhanen_US
dc.contributor.authorSari, Nerimanen_US
dc.contributor.authorSerra, Massimoen_US
dc.contributor.authorHattinger, Claudiaen_US
dc.contributor.authorPicci, Pieroen_US
dc.contributor.authorSpector, Loganen_US
dc.contributor.authorBarkauskas, Donald A.en_US
dc.contributor.authorMarina, Neyssaen_US
dc.contributor.authorde Toledo, Silvia Regina Caminadaen_US
dc.contributor.authorPetrilli, Antonio S.en_US
dc.contributor.authorAmary, Maria Fernandaen_US
dc.contributor.authorHalai, Dinaen_US
dc.contributor.authorThomas, David M.en_US
dc.contributor.authorDouglass, Chesteren_US
dc.contributor.authorMeltzer, Paul S.en_US
dc.contributor.authorJacobs, Kevinen_US
dc.contributor.authorChung, Charles C.en_US
dc.contributor.authorBerndt, Sonja I.en_US
dc.contributor.authorPurdue, Mark P.en_US
dc.contributor.authorCaporaso, Neil E.en_US
dc.contributor.authorTucker, Margareten_US
dc.contributor.authorRothman, Nathanielen_US
dc.contributor.authorLandi, Maria Teresaen_US
dc.contributor.authorSilverman, Debra T.en_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorMalats, Nuriaen_US
dc.contributor.authorKogevinas, Manolisen_US
dc.contributor.authorWacholder, Sholomen_US
dc.contributor.authorTroisi, Rebeccaen_US
dc.contributor.authorHelman, Leeen_US
dc.contributor.authorFraumeni, Joseph F.en_US
dc.contributor.authorYeager, Meredithen_US
dc.contributor.authorHoover, Robert N.en_US
dc.contributor.authorChanock, Stephen J.en_US
dc.date.accessioned2014-03-11T13:52:28Z
dc.date.issued2013en_US
dc.identifier.citationSavage, S. A., L. Mirabello, Z. Wang, J. M. Gastier-Foster, R. Gorlick, C. Khanna, A. M. Flanagan, et al. 2013. “Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma.” Nature genetics 45 (7): 799-803. doi:10.1038/ng.2645. http://dx.doi.org/10.1038/ng.2645.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879782
dc.description.abstractOsteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) consisting of 941 cases and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: rs1906953 at 6p21.3, in the glutamate receptor metabotropic 4 [GRM4] gene (P = 8.1 ×10-9), and rs7591996 and rs10208273 in a gene desert on 2p25.2 (P = 1.0 ×10-8 and 2.9 ×10-7). These two susceptibility loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.2645en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910497/pdf/en
dash.licenseLAAen_US
dc.titleGenome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcomaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorDouglass, Chesteren_US
dc.date.available2014-03-11T13:52:28Z
dc.identifier.doi10.1038/ng.2645*
dash.authorsorderedfalse
dash.contributor.affiliatedDouglass, Chester
dash.contributor.affiliatedKraft, Phillip
dash.contributor.affiliatedHunter, David


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