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dc.contributor.authorYo, Chia-Hungen_US
dc.contributor.authorLee, Si-Hueien_US
dc.contributor.authorChang, Shy-Shinen_US
dc.contributor.authorLee, Matthew Chien-Hungen_US
dc.contributor.authorLee, Chien-Changen_US
dc.date.accessioned2014-03-11T13:52:42Z
dc.date.issued2014en_US
dc.identifier.citationYo, Chia-Hung, Si-Huei Lee, Shy-Shin Chang, Matthew Chien-Hung Lee, and Chien-Chang Lee. 2014. “Value of high-sensitivity C-reactive protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysis.” BMJ Open 4 (2): e004418. doi:10.1136/bmjopen-2013-004418. http://dx.doi.org/10.1136/bmjopen-2013-004418.en
dc.identifier.issn2044-6055en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879793
dc.description.abstractObjectives: We performed a systematic review and meta-analysis of studies on high-sensitivity C-reactive protein (hs-CRP) assays to see whether these tests are predictive of atrial fibrillation (AF) recurrence after cardioversion. Design: Systematic review and meta-analysis. Data sources PubMed, EMBASE and Cochrane databases as well as a hand search of the reference lists in the retrieved articles from inception to December 2013. Study eligibility criteria This review selected observational studies in which the measurements of serum CRP were used to predict AF recurrence. An hs-CRP assay was defined as any CRP test capable of measuring serum CRP to below 0.6 mg/dL. Primary and secondary outcome measures We summarised test performance characteristics with the use of forest plots, hierarchical summary receiver operating characteristic curves and bivariate random effects models. Meta-regression analysis was performed to explore the source of heterogeneity. Results: We included nine qualifying studies comprising a total of 347 patients with AF recurrence and 335 controls. A CRP level higher than the optimal cut-off point was an independent predictor of AF recurrence after cardioversion (summary adjusted OR: 3.33; 95% CI 2.10 to 5.28). The estimated pooled sensitivity and specificity for hs-CRP was 71.0% (95% CI 63% to 78%) and 72.0% (61% to 81%), respectively. Most studies used a CRP cut-off point of 1.9 mg/L to predict long-term AF recurrence (77% sensitivity, 65% specificity), and 3 mg/L to predict short-term AF recurrence (73% sensitivity, 71% specificity). Conclusions: hs-CRP assays are moderately accurate in predicting AF recurrence after successful cardioversion.en
dc.language.isoen_USen
dc.publisherBMJ Publishing Groupen
dc.relation.isversionofdoi:10.1136/bmjopen-2013-004418en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931987/pdf/en
dash.licenseLAAen_US
dc.subjectC - reactive proteinen
dc.subjectcardioversionen
dc.subjectmeta-analysisen
dc.titleValue of high-sensitivity C-reactive protein assays in predicting atrial fibrillation recurrence: a systematic review and meta-analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMJ Openen
dash.depositing.authorLee, Chien-Changen_US
dc.date.available2014-03-11T13:52:42Z
dc.identifier.doi10.1136/bmjopen-2013-004418*
dash.authorsorderedfalse
dash.contributor.affiliatedLee, Chien-Chang


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