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dc.contributor.authorLang, Gregory I.en_US
dc.contributor.authorRice, Daniel P.en_US
dc.contributor.authorHickman, Mark J.en_US
dc.contributor.authorSodergren, Ericaen_US
dc.contributor.authorWeinstock, George M.en_US
dc.contributor.authorBotstein, Daviden_US
dc.contributor.authorDesai, Michael M.en_US
dc.date.accessioned2014-03-11T13:53:05Z
dc.date.issued2013en_US
dc.identifier.citationLang, Gregory I., Daniel P. Rice, Mark J. Hickman, Erica Sodergren, George M. Weinstock, David Botstein, and Michael M. Desai. 2013. “Pervasive Genetic Hitchhiking and Clonal Interference in 40 Evolving Yeast Populations.” Nature 500 (7464): 571-574. doi:10.1038/nature12344. http://dx.doi.org/10.1038/nature12344.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879818
dc.description.abstractThe dynamics of adaptation determines which mutations fix in a population, and hence how reproducible evolution will be. This is central to understanding the spectra of mutations recovered in evolution of antibiotic resistance1, the response of pathogens to immune selection2,3, and the dynamics of cancer progression4,5. In laboratory evolution experiments, demonstrably beneficial mutations are found repeatedly6–8, but are often accompanied by other mutations with no obvious benefit. Here we use whole-genome whole-population sequencing to examine the dynamics of genome sequence evolution at high temporal resolution in 40 replicate Saccharomyces cerevisiae populations growing in rich medium for 1,000 generations. We find pervasive genetic hitchhiking: multiple mutations arise and move synchronously through the population as mutational “cohorts.” Multiple clonal cohorts are often present simultaneously, competing with each other in the same population. Our results show that patterns of sequence evolution are driven by a balance between these chance effects of hitchhiking and interference, which increase stochastic variation in evolutionary outcomes, and the deterministic action of selection on individual mutations, which favors parallel evolutionary solutions in replicate populations.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature12344en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758440/pdf/en
dash.licenseLAAen_US
dc.titlePervasive Genetic Hitchhiking and Clonal Interference in 40 Evolving Yeast Populationsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorRice, Daniel P.en_US
dc.date.available2014-03-11T13:53:05Z
dc.identifier.doi10.1038/nature12344*
dash.contributor.affiliatedRice, Daniel
dash.contributor.affiliatedDesai, Michael


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