Crossover Patterning by the Beam-Film Model: Analysis and Implications

DSpace/Manakin Repository

Crossover Patterning by the Beam-Film Model: Analysis and Implications

Citable link to this page

 

 
Title: Crossover Patterning by the Beam-Film Model: Analysis and Implications
Author: Zhang, Liangran; Liang, Zhangyi; Hutchinson, John; Kleckner, Nancy

Note: Order does not necessarily reflect citation order of authors.

Citation: Zhang, Liangran, Zhangyi Liang, John Hutchinson, and Nancy Kleckner. 2014. “Crossover Patterning by the Beam-Film Model: Analysis and Implications.” PLoS Genetics 10 (1): e1004042. doi:10.1371/journal.pgen.1004042. http://dx.doi.org/10.1371/journal.pgen.1004042.
Full Text & Related Files:
Abstract: Crossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena: CO homeostasis, the fact that the level of zero-CO bivalents can be low (the “obligatory CO”), and the occurrence of non-interfering COs. Relationships to other models are discussed.
Published Version: doi:10.1371/journal.pgen.1004042
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907302/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879819
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters