Show simple item record

dc.contributor.authorAnnese, Jacopoen_US
dc.contributor.authorSchenker-Ahmed, Natalie M.en_US
dc.contributor.authorBartsch, Haukeen_US
dc.contributor.authorMaechler, Paulen_US
dc.contributor.authorSheh, Colleenen_US
dc.contributor.authorThomas, Natashaen_US
dc.contributor.authorKayano, Junyaen_US
dc.contributor.authorGhatan, Alexanderen_US
dc.contributor.authorBresler, Noahen_US
dc.contributor.authorFrosch, Matthew P.en_US
dc.contributor.authorKlaming, Ruthen_US
dc.contributor.authorCorkin, Suzanneen_US
dc.date.accessioned2014-03-11T13:53:22Z
dc.date.issued2014en_US
dc.identifier.citationAnnese, J., N. M. Schenker-Ahmed, H. Bartsch, P. Maechler, C. Sheh, N. Thomas, J. Kayano, et al. 2014. “Postmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction.” Nature Communications 5 (1): 3122. doi:10.1038/ncomms4122. http://dx.doi.org/10.1038/ncomms4122.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879833
dc.description.abstractModern scientific knowledge of how memory functions are organized in the human brain originated from the case of Henry G. Molaison (H.M.), an epileptic patient whose amnesia ensued unexpectedly following a bilateral surgical ablation of medial temporal lobe structures, including the hippocampus. The neuroanatomical extent of the 1953 operation could not be assessed definitively during H.M.’s life. Here we describe the results of a procedure designed to reconstruct a microscopic anatomical model of the whole brain and conduct detailed 3D measurements in the medial temporal lobe region. This approach, combined with cellular-level imaging of stained histological slices, demonstrates a significant amount of residual hippocampal tissue with distinctive cytoarchitecture. Our study also reveals diffuse pathology in the deep white matter and a small, circumscribed lesion in the left orbitofrontal cortex. The findings constitute new evidence that may help elucidate the consequences of H.M.’s operation in the context of the brain’s overall pathology.en
dc.language.isoen_USen
dc.publisherNature Pub. Groupen
dc.relation.isversionofdoi:10.1038/ncomms4122en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916843/pdf/en
dash.licenseLAAen_US
dc.titlePostmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstructionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorFrosch, Matthew P.en_US
dc.date.available2014-03-11T13:53:22Z
dc.identifier.doi10.1038/ncomms4122*
dash.authorsorderedfalse
dash.contributor.affiliatedFrosch, Matthew


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record