Macrophages in pancreatic cancer: Starting things off on the wrong track
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CitationDeschênes-Simard, Xavier, Yusuke Mizukami, and Nabeel Bardeesy. 2013. “Macrophages in pancreatic cancer: Starting things off on the wrong track.” The Journal of Cell Biology 202 (3): 403-405. doi:10.1083/jcb.201307066. http://dx.doi.org/10.1083/jcb.201307066.
AbstractChronic inflammation drives initiation and progression of many malignancies, including pancreatic cancer. In this issue, Liou et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201301001) report that inflammatory macrophages are major players in the earliest stages of pancreatic cancer. They show that paracrine signals from the macrophages activate the nuclear factor κB transcriptional program in normal pancreatic acinar cells, resulting in acinar–ductal metaplasia, a dedifferentiated state that is poised for oncogenic transformation.
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