Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4
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CitationMikhak, Zamaneh, James P. Strassner, and Andrew D. Luster. 2013. “Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4.” The Journal of Experimental Medicine 210 (9): 1855-1869. doi:10.1084/jem.20130091. http://dx.doi.org/10.1084/jem.20130091.
AbstractT cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC–activated T cells traffic more efficiently into the lung in response to inhaled antigen and at homeostasis compared with T cells activated by DCs from other tissues. Consequently, lung DC–imprinted T cells protect against influenza more effectively than do gut and skin DC–imprinted T cells. Lung DCs imprint the expression of CCR4 on T cells, and CCR4 contributes to T cell lung imprinting. Lung DC–activated, CCR4-deficient T cells fail to traffic into the lung as efficiently and to protect against influenza as effectively as lung DC–activated, CCR4-sufficient T cells. Thus, lung DCs imprint T cell lung homing and promote lung immunity in part through CCR4.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879883
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