dc.contributor.author | Mikhak, Zamaneh | en_US |
dc.contributor.author | Strassner, James P. | en_US |
dc.contributor.author | Luster, Andrew D. | en_US |
dc.date.accessioned | 2014-03-11T13:53:46Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Mikhak, Zamaneh, James P. Strassner, and Andrew D. Luster. 2013. “Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4.” The Journal of Experimental Medicine 210 (9): 1855-1869. doi:10.1084/jem.20130091. http://dx.doi.org/10.1084/jem.20130091. | en |
dc.identifier.issn | 0022-1007 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879883 | |
dc.description.abstract | T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC–activated T cells traffic more efficiently into the lung in response to inhaled antigen and at homeostasis compared with T cells activated by DCs from other tissues. Consequently, lung DC–imprinted T cells protect against influenza more effectively than do gut and skin DC–imprinted T cells. Lung DCs imprint the expression of CCR4 on T cells, and CCR4 contributes to T cell lung imprinting. Lung DC–activated, CCR4-deficient T cells fail to traffic into the lung as efficiently and to protect against influenza as effectively as lung DC–activated, CCR4-sufficient T cells. Thus, lung DCs imprint T cell lung homing and promote lung immunity in part through CCR4. | en |
dc.language.iso | en_US | en |
dc.publisher | The Rockefeller University Press | en |
dc.relation.isversionof | doi:10.1084/jem.20130091 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754856/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4 | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | The Journal of Experimental Medicine | en |
dash.depositing.author | Mikhak, Zamaneh | en_US |
dc.date.available | 2014-03-11T13:53:46Z | |
dc.identifier.doi | 10.1084/jem.20130091 | * |
dash.contributor.affiliated | Mikhak, Zamaneh | |
dash.contributor.affiliated | Luster, Andrew | |