TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling
Palapetta, Shyam Mohan
Prasad, T. S. Keshava
Tyner, Jeffrey W.
van Bodegom, Diederik
Ziegler, Steven F.
Pandey, AkhileshNote: Order does not necessarily reflect citation order of authors.
MetadataShow full item record
CitationZhong, J., J. Sharma, R. Raju, S. M. Palapetta, T. S. K. Prasad, T. Huang, A. Yoda, et al. 2014. “TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.” Database: The Journal of Biological Databases and Curation 2014 (1): bau007. doi:10.1093/database/bau007. http://dx.doi.org/10.1093/database/bau007.
AbstractThymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11879894
- HMS Scholarly Articles 
Contact administrator regarding this item (to report mistakes or request changes)