Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick

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Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick

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Title: Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick
Author: Vella, Sarah J.; Beattie, Patrick; Cademartiri, Rebecca; Laromaine, Anna; Martinez, Andres W.; Phillips, Scott T.; Mirica, Katherine A.; Whitesides, George McClelland

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Citation: Vella, Sarah J., Patrick Beattie, Rebecca Cademartiri, Anna Laromaine, Andres W. Martinez, Scott T. Phillips, Katherine A. Mirica, and George M. Whitesides. 2012. Measuring Markers of Liver Function Using a Micropatterned Paper Device Designed for Blood from a Fingerstick. Analytical Chemistry 84, no. 6: 2883–2891.
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Abstract: This paper describes a paper-based microfluidic device that measures two enzymatic markers of liver function (alkaline phosphatase, ALP, and aspartate aminotransferase, AST) and total serum protein. A device consists of four components: (i) a top plastic sheet, (ii) a filter membrane, (iii) a patterned paper chip containing the reagents necessary for analysis, and (iv) a bottom plastic sheet. The device performs both the sample preparation (separating blood plasma from erythrocytes) and the assays; it also enables both qualitative and quantitative analysis of data. The data obtained from the paper-microfluidic devices show standard deviations in calibration runs and “spiked” standards that are acceptable for routine clinical use. This device illustrates a type of test useable for a range of assays in resource-poor settings.
Published Version: doi:10.1021/ac203434x
Other Sources: gmwgroup.harvard.edu/pubs/pdf/1143.pdf‎
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11956907
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