Noise-Driven Stem Cell and Progenitor Population Dynamics

DSpace/Manakin Repository

Noise-Driven Stem Cell and Progenitor Population Dynamics

Citable link to this page

 

 
Title: Noise-Driven Stem Cell and Progenitor Population Dynamics
Author: Hoffmann, Martin; Chang, Hannah Han-Chun; Hang, Sui; Ingber, Donald Elliott; Loeffler, Markus; Galle, Joerg

Note: Order does not necessarily reflect citation order of authors.

Citation: Hoffmann, Martin, Hannah H. Chang, Sui Huang, Donald E. Ingber, Markus Loeffler, and Joerg Galle. 2008. Noise-driven stem cell and progenitor population dynamics. PLoS One 3(8): e2922.
Full Text & Related Files:
Abstract: BACKGROUND: The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment. The switching between these states has long been understood as a transition between attractor states of a molecular network. Herein, stochastic fluctuations are either suppressed or can trigger the transition, but they do not actually determine the attractor states. METHODOLOGY/PRINCIPAL FINDINGS: We present a novel mathematical concept in which stem cell and progenitor population dynamics are described as a probabilistic process that arises from cell proliferation and small fluctuations in the state of differentiation. These state fluctuations reflect random transitions between different activation patterns of the underlying regulatory network. Importantly, the associated noise amplitudes are state-dependent and set by the environment. Their variability determines the attractor states, and thus actually governs population dynamics. This model quantitatively reproduces the observed dynamics of differentiation and dedifferentiation in promyelocytic precursor cells. CONCLUSIONS/SIGNIFICANCE: Consequently, state-specific noise modulation by external signals can be instrumental in controlling stem cell and progenitor population dynamics. We propose follow-up experiments for quantifying the imprinting influence of the environment on cellular noise regulation.
Published Version: http://dx.doi.org/10.1371/journal.pone.0002922
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488392/pdf/pone.0002922.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11987421
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters