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dc.contributor.authorEum, Ki-Doen_US
dc.contributor.authorWeisskopf, Marc G.en_US
dc.contributor.authorNie, Linda H.en_US
dc.contributor.authorHu, Howarden_US
dc.contributor.authorKorrick, Susan A.en_US
dc.date.accessioned2014-04-11T14:11:01Z
dc.date.issued2014en_US
dc.identifier.citationEum, Ki-Do, Marc G. Weisskopf, Linda H. Nie, Howard Hu, and Susan A. Korrick. 2014. “Cumulative Lead Exposure and Age at Menopause in the Nurses’ Health Study Cohort.” Environmental Health Perspectives 122 (3): 229-234. doi:10.1289/ehp.1206399. http://dx.doi.org/10.1289/ehp.1206399.en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12064373
dc.description.abstractBackground: Early menopause has been associated with many adverse health outcomes, including increased risk of cardiovascular disease morbidity and mortality. Lead has been found to be adversely associated with female reproductive function, but whether exposures experienced by the general population are associated with altered age at menopause has not been explored. Objective: Our goal was to assess the association between cumulative lead exposure and age at natural menopause. Methods: Self-reported menopausal status and bone lead concentration measured with K-shell X-ray fluorescence—a biomarker of cumulative lead exposure—were obtained from 434 women participants in the Nurses’ Health Study. Results: The mean (± SD) age at natural menopause was 50.8 ± 3.6 years. Higher tibia lead level was associated with younger age at menopause. In adjusted analyses, the average age of menopause for women in the highest tertile of tibia lead was 1.21 years younger (95% CI: –2.08, –0.35) than for women in the lowest tertile (p-trend = 0.006). Although the number of cases was small (n = 23), the odds ratio for early menopause (< 45 years of age) was 5.30 (95% CI: 1.42, 19.78) for women in the highest tertile of tibia lead compared with those in the lowest tertile (p-trend = 0.006). There was no association between patella or blood lead and age at menopause. Conclusions: Our results support an association between low-level cumulative lead exposure and an earlier age at menopause. These data suggest that low-level lead exposure may contribute to menopause-related health outcomes in older women through effects on age at menopause. Citation: Eum KD, Weisskopf MG, Nie LH, Hu H, Korrick SA. 2014. Cumulative lead exposure and age at menopause in the Nurses’ Health Study Cohort. Environ Health Perspect 122:229–234; http://dx.doi.org/10.1289/ehp.1206399en
dc.language.isoen_USen
dc.publisherNational Institute of Environmental Health Sciencesen
dc.relation.isversionofdoi:10.1289/ehp.1206399en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948024/pdf/en
dash.licenseLAAen_US
dc.titleCumulative Lead Exposure and Age at Menopause in the Nurses’ Health Study Cohorten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Health Perspectivesen
dash.depositing.authorWeisskopf, Marc G.en_US
dc.date.available2014-04-11T14:11:01Z
dc.identifier.doi10.1289/ehp.1206399*
dash.contributor.affiliatedKorrick, Susan
dash.contributor.affiliatedWeisskopf, Marc


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