Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection
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Author
Huang, Bor-Ren
Chang, Pei-Chun
Yeh, Wei-Lan
Tsai, Cheng-Fang
Lin, Chingju
Lin, Hsiao-Yun
Liu, Yu-Shu
Wu, Caren Yu-Ju
Ko, Pei-Ying
Huang, Shiang-Suo
Hsu, Horng-Chaung
Lu, Dah-Yuu
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1371/journal.pone.0091167Metadata
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Huang, B., P. Chang, W. Yeh, C. Lee, C. Tsai, C. Lin, H. Lin, et al. 2014. “Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection.” PLoS ONE 9 (3): e91167. doi:10.1371/journal.pone.0091167. http://dx.doi.org/10.1371/journal.pone.0091167.Abstract
Background/Objective Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. However, accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in neurodegeneration, and the effect of nicardipine on microglial activation remains unresolved. Methodology/Principal Findings In the present study, using murine BV-2 microglia, we demonstrated that nicardipine significantly inhibits microglia-related neuroinflammatory responses. Treatment with nicardipine inhibited microglial cell migration. Nicardipine also significantly inhibited LPS plus IFN-γ-induced release of nitric oxide (NO), and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, nicardipine also inhibited microglial activation by peptidoglycan, the major component of the Gram-positive bacterium cell wall. Notably, nicardipine also showed significant anti-neuroinflammatory effects on microglial activation in mice in vivo. Conclusion/Significance The present study is the first to report a novel inhibitory role of nicardipine on neuroinflammation and provides a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951295/pdf/Terms of Use
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