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dc.contributor.authorRyter, Stefan W.en_US
dc.contributor.authorMizumura, Kenjien_US
dc.contributor.authorChoi, Augustine M. K.en_US
dc.date.accessioned2014-04-11T14:12:58Z
dc.date.issued2014en_US
dc.identifier.citationRyter, Stefan W., Kenji Mizumura, and Augustine M. K. Choi. 2014. “The Impact of Autophagy on Cell Death Modalities.” International Journal of Cell Biology 2014 (1): 502676. doi:10.1155/2014/502676. http://dx.doi.org/10.1155/2014/502676.en
dc.identifier.issn1687-8876en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12064524
dc.description.abstractAutophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway. During starvation, autophagy facilitates cell survival through the recycling of metabolic precursors. Additionally, autophagy can modulate other vital processes such as programmed cell death (e.g., apoptosis), inflammation, and adaptive immune mechanisms and thereby influence disease pathogenesis. Selective pathways can target distinct cargoes (e.g., mitochondria and proteins) for autophagic degradation. At present, the causal relationship between autophagy and various forms of regulated or nonregulated cell death remains unclear. Autophagy can occur in association with necrosis-like cell death triggered by caspase inhibition. Autophagy and apoptosis have been shown to be coincident or antagonistic, depending on experimental context, and share cross-talk between signal transduction elements. Autophagy may modulate the outcome of other regulated forms of cell death such as necroptosis. Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines. Autophagy may also act as regulator of caspase-1 dependent cell death (pyroptosis). Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases in which apoptosis or other forms of regulated cell death may play a cardinal role.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2014/502676en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932252/pdf/en
dash.licenseLAAen_US
dc.titleThe Impact of Autophagy on Cell Death Modalitiesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalInternational Journal of Cell Biologyen
dash.depositing.authorRyter, Stefan W.en_US
dc.date.available2014-04-11T14:12:58Z
dc.identifier.doi10.1155/2014/502676*
dash.contributor.affiliatedRyter, Stefan W.


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