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dc.contributor.authorTeismann, Henningen_US
dc.contributor.authorWollbrink, Andreasen_US
dc.contributor.authorOkamoto, Hidehikoen_US
dc.contributor.authorSchlaug, Gottfrieden_US
dc.contributor.authorRudack, Claudiaen_US
dc.contributor.authorPantev, Christoen_US
dc.date.accessioned2014-04-11T14:13:01Z
dc.date.issued2014en_US
dc.identifier.citationTeismann, Henning, Andreas Wollbrink, Hidehiko Okamoto, Gottfried Schlaug, Claudia Rudack, and Christo Pantev. 2014. “Combining Transcranial Direct Current Stimulation and Tailor-Made Notched Music Training to Decrease Tinnitus-Related Distress – A Pilot Study.” PLoS ONE 9 (2): e89904. doi:10.1371/journal.pone.0089904. http://dx.doi.org/10.1371/journal.pone.0089904.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12064529
dc.description.abstractThe central auditory system has a crucial role in tinnitus generation and maintenance. Curative treatments for tinnitus do not yet exist. However, recent attempts in the therapeutic application of both acoustic stimulation/training procedures and electric/magnetic brain stimulation techniques have yielded promising results. Here, for the first time we combined tailor-made notched music training (TMNMT) with transcranial direct current stimulation (tDCS) in an effort to modulate TMNMT efficacy in the treatment of 32 patients with tonal tinnitus and without severe hearing loss. TMNMT is characterized by regular listening to so-called notched music, which is generated by digitally removing the frequency band of one octave width centered at the individual tinnitus frequency. TMNMT was applied for 10 subsequent days (2.5 hours of daily treatment). During the initial 5 days of treatment and the initial 30 minutes of TMNMT sessions, tDCS (current strength: 2 mA; anodal (N = 10) vs. cathodal (N = 11) vs. sham (N = 11) groups) was applied simultaneously. The active electrode was placed on the head surface over left auditory cortex; the reference electrode was put over right supra-orbital cortex. To evaluate treatment outcome, tinnitus-related distress and perceived tinnitus loudness were assessed using standardized tinnitus questionnaires and a visual analogue scale. The results showed a significant treatment effect reflected in the Tinnitus Handicap Questionnaire that was largest after 5 days of treatment. This effect remained significant at the end of follow-up 31 days after treatment cessation. Crucially, tDCS did not significantly modulate treatment efficacy - it did not make a difference whether anodal, cathodal, or sham tDCS was applied. Possible explanations for the findings and functional modifications of the experimental design for future studies (e.g. the selection of control conditions) are discussed.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0089904en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934956/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectAnatomy and physiologyen
dc.subjectNeuroscienceen
dc.subjectSensory systemsen
dc.subjectAuditory systemen
dc.subjectMedicineen
dc.subjectOtorhinolaryngologyen
dc.subjectSocial and behavioral sciencesen
dc.subjectPsychologyen
dc.titleCombining Transcranial Direct Current Stimulation and Tailor-Made Notched Music Training to Decrease Tinnitus-Related Distress – A Pilot Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorSchlaug, Gottfrieden_US
dc.date.available2014-04-11T14:13:01Z
dc.identifier.doi10.1371/journal.pone.0089904*
dash.contributor.affiliatedSchlaug, Gottfried


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