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dc.contributor.authorBarski, Jaroslaw J.en_US
dc.contributor.authorDenker, Brad M.en_US
dc.contributor.authorGuan, Jiazhenen_US
dc.contributor.authorLauth, Matthiasen_US
dc.contributor.authorSpreafico, Fabioen_US
dc.contributor.authorFertala, Andrzejen_US
dc.contributor.authorMeyer, Michaelen_US
dc.date.accessioned2014-04-11T14:13:10Z
dc.date.issued2013en_US
dc.identifier.citationBarski, Jaroslaw J., Brad M. Denker, Jiazhen Guan, Matthias Lauth, Fabio Spreafico, Andrzej Fertala, and Michael Meyer. 2013. “Developmental Upregulation of an Alternative Form of pcp2 with Reduced GDI Activity.” Cerebellum (London, England) 13 (1): 207-214. doi:10.1007/s12311-013-0529-0. http://dx.doi.org/10.1007/s12311-013-0529-0.en
dc.identifier.issn1473-4222en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12064546
dc.description.abstractThe pcp2/L7 gene is characterized by its very cell type-specific expression restricted to cerebellar Purkinje cells and retinal bipolar neurons. Although remarkable progress as to the biochemical properties of the encoded protein has been made, knowledge on its physiological functions remains sparse. While characterizing a pcp2-driven transgenic strain, we observed the presence of a longer, so far unknown, pcp2 transcript. Different from another recently discovered splice variant, ret-pcp2, expression of this novel transcript is observed in bipolar as well as cerebellar Purkinje cells of mid-postnatal mice. The protein encoded by our novel variant appears to be less efficient in binding to Gα subunits compared to the original L7/pcp2 protein and it is also less inhibitory with respect to GTPγ binding. Its expression in the eye appears to be independent from eye opening in postnatal mice.en
dc.language.isoen_USen
dc.publisherSpringer USen
dc.relation.isversionofdoi:10.1007/s12311-013-0529-0en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939015/pdf/en
dash.licenseLAAen_US
dc.subjectpcp2en
dc.subjectL7en
dc.subjectSplice varianten
dc.subjectCerebellumen
dc.titleDevelopmental Upregulation of an Alternative Form of pcp2 with Reduced GDI Activityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCerebellum (London, England)en
dc.date.available2014-04-11T14:13:10Z
dc.identifier.doi10.1007/s12311-013-0529-0*


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