Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence

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Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence

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Title: Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence
Author: Moyo, Sikhulile; LeCuyer, Tessa; Wang, Rui; Gaseitsiwe, Simani; Weng, Jia; Musonda, Rosemary Mubanga; Bussmann, Hermann; Mine, Madisa; Engelbrecht, Susan; Makhema, Joseph Moeketsi; Marlink, Richard G.; Baum, Marianna K.; Novitsky, Vladimir A.; Essex, Myron Elmer

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Citation: Moyo, Sikhulile, Tessa LeCuyer, Rui Wang, Simani Gaseitsiwe, Jia Weng, Rosemary Musonda, Hermann Bussmann, et al. 2014. Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence. AIDS Research and Human Retroviruses 30, no. 1: 29–36.
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Abstract: Laboratory cross-sectional assays are useful for the estimation of HIV incidence, but are known to misclassify individuals with long-standing infection as recently infected. The false recent rate (FRR) varies widely across geographic areas; therefore, accurate estimates of HIV incidence require a locally defined FRR. We determined FRR for Botswana, where HIV-1 subtype C infection is predominant, using the BED capture enzyme immunoassay (BED), a Bio-Rad Avidity Index (BAI) assay (a modification of the Bio-Rad HIV1/2+O EIA), and two multiassay algorithms (MAA) that included clinical data. To estimate FRR, stored blood samples from 512 antiretroviral (ARV)-naive HIV-1 subtype C-infected individuals from a prospective cohort in Botswana were tested at 18-24 months postenrollment. The following FRR mean (95% CI) values were obtained: BED 6.05% (4.15-8.48), BAI 5.57% (3.70-8.0), BED-BAI 2.25% (1.13-4.0), and a combination of BED-BAI with CD4 (>200) and viral load (>400) threshold 1.43% (0.58-2.93). The interassay agreement between BED and BAI was 92.8% (95% CI, 90.1-94.5) for recent/long-term classification. Misclassification was associated with viral suppression for BED [adjusted OR (aOR) 10.31; p=0.008], BAI [aOR 9.72; p=0.019], and MAA1 [aOR 16.6; p=0.006]. Employing MAA can reduce FRR to <2%. A local FRR can improve cross-sectional HIV incidence estimates.
Published Version: 10.1089/aid.2013.0055
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12098691
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