The Role of Animal Models for Research on Severe Malaria
Craig, Alister G.
Grau, Georges E.
Kazura, James W.
Barnwell, John W.
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CitationCraig, Alister G., Georges E. Grau, Chris Janse, James W. Kazura, Danny Arnold Milner, John W. Barnwell, Gareth Turner, and Jean Langhorne. 2012. “The Role of Animal Models for Research on Severe Malaria.” PLoS Pathogens 8(2) (February 2): e1002401. doi:10.1371/journal.ppat.1002401. http://dx.doi.org/10.1371/journal.ppat.1002401.
AbstractIn light of the recent controversies over the role of animal models for research into the development of new treatments for severe malaria, particularly cerebral disease, a group of scientists came together to discuss the relative merits of a range of animal models and their overlap with the complex clinical syndromes of human disease. While it was not possible to fully resolve differences over the utility of the Plasmodium berghei ANKA model of experimental cerebral malaria, the meeting did bring the two research communities closer together to identify further work to provide information needed to validate the model and revitalise the development of other animal models displaying features of human pathology. The driving force behind this was the desire to ensure better translation of experimental findings into effective treatments for severe malaria.
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