dc.contributor.author | Chung, Jean-Ju | en_US |
dc.contributor.author | Navarro, Betsy | en_US |
dc.contributor.author | Krapivinsky, Grigory | en_US |
dc.contributor.author | Krapivinsky, Luba | en_US |
dc.contributor.author | Clapham, David E. | en_US |
dc.date.accessioned | 2014-05-06T16:15:48Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Chung, Jean-Ju, Betsy Navarro, Grigory Krapivinsky, Luba Krapivinsky, and David E. Clapham. 2014. “A Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoa.” Nature communications 2 (1): 153. doi:10.1038/ncomms1153. http://dx.doi.org/10.1038/ncomms1153. | en |
dc.identifier.issn | 2041-1723 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152829 | |
dc.description.abstract | Summary Calcium signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility, and the acrosome reaction are all mediated by increases in intracellular Ca2+. Cation channels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca2+-selective channel required for the hyperactivated motility of spermatozoa and male fertility. Each of the CatSper1-4 genes encodes a subunit of a tetramer surrounding a Ca2+-selective pore, in analogy with other six-transmembrane ion channel α subunits. In addition to the pore-forming proteins, the sperm Ca2+ channel contains auxiliary subunits, CATSPERβ and CATSPERγ. Here, we identify the Tmem146 gene product as a novel subunit, CATSPERδ, required for CATSPER channel function. We find that mice lacking the sperm tail-specific CATSPERδ are infertile and their spermatozoa lack both Ca2+ current and hyperactivated motility. We show that CATSPERδ is an essential element of the CATSPER channel complex and propose that CATSPERδ is required for proper CATSPER channel assembly and/or transport. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ncomms1153 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999383/pdf/ | en |
dash.license | LAA | en_US |
dc.title | A Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoa | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature communications | en |
dash.depositing.author | Chung, Jean-Ju | en_US |
dc.date.available | 2014-05-06T16:15:48Z | |
dc.identifier.doi | 10.1038/ncomms1153 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Krapivinsky, Grigory | |
dash.contributor.affiliated | Chung, Jean-Ju | |
dash.contributor.affiliated | Clapham, David | |