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dc.contributor.authorChung, Jean-Juen_US
dc.contributor.authorNavarro, Betsyen_US
dc.contributor.authorKrapivinsky, Grigoryen_US
dc.contributor.authorKrapivinsky, Lubaen_US
dc.contributor.authorClapham, David E.en_US
dc.date.accessioned2014-05-06T16:15:48Z
dc.date.issued2014en_US
dc.identifier.citationChung, Jean-Ju, Betsy Navarro, Grigory Krapivinsky, Luba Krapivinsky, and David E. Clapham. 2014. “A Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoa.” Nature communications 2 (1): 153. doi:10.1038/ncomms1153. http://dx.doi.org/10.1038/ncomms1153.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12152829
dc.description.abstractSummary Calcium signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility, and the acrosome reaction are all mediated by increases in intracellular Ca2+. Cation channels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca2+-selective channel required for the hyperactivated motility of spermatozoa and male fertility. Each of the CatSper1-4 genes encodes a subunit of a tetramer surrounding a Ca2+-selective pore, in analogy with other six-transmembrane ion channel α subunits. In addition to the pore-forming proteins, the sperm Ca2+ channel contains auxiliary subunits, CATSPERβ and CATSPERγ. Here, we identify the Tmem146 gene product as a novel subunit, CATSPERδ, required for CATSPER channel function. We find that mice lacking the sperm tail-specific CATSPERδ are infertile and their spermatozoa lack both Ca2+ current and hyperactivated motility. We show that CATSPERδ is an essential element of the CATSPER channel complex and propose that CATSPERδ is required for proper CATSPER channel assembly and/or transport.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncomms1153en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999383/pdf/en
dash.licenseLAAen_US
dc.titleA Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature communicationsen
dash.depositing.authorChung, Jean-Juen_US
dc.date.available2014-05-06T16:15:48Z
dc.identifier.doi10.1038/ncomms1153*
dash.authorsorderedfalse
dash.contributor.affiliatedKrapivinsky, Grigory
dash.contributor.affiliatedChung, Jean-Ju
dash.contributor.affiliatedClapham, David


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