Show simple item record

dc.contributor.authorBurnett, Richard T.en_US
dc.contributor.authorPope, C. Ardenen_US
dc.contributor.authorEzzati, Majiden_US
dc.contributor.authorOlives, Caseyen_US
dc.contributor.authorLim, Stephen S.en_US
dc.contributor.authorMehta, Sumien_US
dc.contributor.authorShin, Hwashin H.en_US
dc.contributor.authorSingh, Gitanjalien_US
dc.contributor.authorHubbell, Bryanen_US
dc.contributor.authorBrauer, Michaelen_US
dc.contributor.authorAnderson, H. Rossen_US
dc.contributor.authorSmith, Kirk R.en_US
dc.contributor.authorBalmes, John R.en_US
dc.contributor.authorBruce, Nigel G.en_US
dc.contributor.authorKan, Haidongen_US
dc.contributor.authorLaden, Francineen_US
dc.contributor.authorPrüss-Ustün, Annetteen_US
dc.contributor.authorTurner, Michelle C.en_US
dc.contributor.authorGapstur, Susan M.en_US
dc.contributor.authorDiver, W. Ryanen_US
dc.contributor.authorCohen, Aaronen_US
dc.date.accessioned2014-05-06T16:16:09Z
dc.date.issued2014en_US
dc.identifier.citationBurnett, R. T., C. A. Pope, M. Ezzati, C. Olives, S. S. Lim, S. Mehta, H. H. Shin, et al. 2014. “An Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposure.” Environmental Health Perspectives 122 (4): 397-403. doi:10.1289/ehp.1307049. http://dx.doi.org/10.1289/ehp.1307049.en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12152840
dc.description.abstractBackground: Estimating the burden of disease attributable to long-term exposure to fine particulate matter (PM2.5) in ambient air requires knowledge of both the shape and magnitude of the relative risk (RR) function. However, adequate direct evidence to identify the shape of the mortality RR functions at the high ambient concentrations observed in many places in the world is lacking. Objective: We developed RR functions over the entire global exposure range for causes of mortality in adults: ischemic heart disease (IHD), cerebrovascular disease (stroke), chronic obstructive pulmonary disease (COPD), and lung cancer (LC). We also developed RR functions for the incidence of acute lower respiratory infection (ALRI) that can be used to estimate mortality and lost-years of healthy life in children < 5 years of age. Methods: We fit an integrated exposure–response (IER) model by integrating available RR information from studies of ambient air pollution (AAP), second hand tobacco smoke, household solid cooking fuel, and active smoking (AS). AS exposures were converted to estimated annual PM2.5 exposure equivalents using inhaled doses of particle mass. We derived population attributable fractions (PAFs) for every country based on estimated worldwide ambient PM2.5 concentrations. Results: The IER model was a superior predictor of RR compared with seven other forms previously used in burden assessments. The percent PAF attributable to AAP exposure varied among countries from 2 to 41 for IHD, 1 to 43 for stroke, < 1 to 21 for COPD, < 1 to 25 for LC, and < 1 to 38 for ALRI. Conclusions: We developed a fine particulate mass–based RR model that covered the global range of exposure by integrating RR information from different combustion types that generate emissions of particulate matter. The model can be updated as new RR information becomes available. Citation: Burnett RT, Pope CA III, Ezzati M, Olives C, Lim SS, Mehta S, Shin HH, Singh G, Hubbell B, Brauer M, Anderson HR, Smith KR, Balmes JR, Bruce NG, Kan H, Laden F, Prüss-Ustün A, Turner MC, Gapstur SM, Diver WR, Cohen A. 2014. An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect 122:397–403; http://dx.doi.org/10.1289/ehp.1307049en
dc.language.isoen_USen
dc.publisherNational Institute of Environmental Health Sciencesen
dc.relation.isversionofdoi:10.1289/ehp.1307049en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984213/pdf/en
dash.licenseLAAen_US
dc.titleAn Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposureen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Health Perspectivesen
dash.depositing.authorSingh, Gitanjalien_US
dc.date.available2014-05-06T16:16:09Z
dc.identifier.doi10.1289/ehp.1307049*
dash.authorsorderedfalse
dash.contributor.affiliatedSingh, Gitanjali
dash.contributor.affiliatedLaden, Francine
dc.identifier.orcid0000-0002-2813-2174


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record