Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells
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Author
Tan, Aaron
Farhatnia, Yasmin
Goh, Debbie
Natasha, G
de Mel, Achala
Lim, Jing
Teoh, Swee-Hin
Malkovskiy, Andrey V
Chawla, Reema
Rajadas, Jayakumar
Cousins, Brian G
Alavijeh, Mohammad S
Seifalian, Alexander M
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1186/1559-4106-8-23Metadata
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Tan, A., Y. Farhatnia, D. Goh, G. Natasha, A. de Mel, J. Lim, S. Teoh, et al. 2013. “Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells.” Biointerphases 8 (1): 22. doi:10.1186/1559-4106-8-23. http://dx.doi.org/10.1186/1559-4106-8-23.Abstract
An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979469/pdf/Terms of Use
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