Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report
Nasr, Moufida Ben
Rastaldi, Maria Pia
Vincent Bonventre, Joseph
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CitationBassi, Roberto, Andrea Vergani, Francesca D’Addio, Moufida Ben Nasr, Alessio Mocci, Maria Pia Rastaldi, Takaharu Ichimura, Joseph Vincent Bonventre, and Paolo Fiorina. 2014. “Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report.” SpringerPlus 3 (1): 158. doi:10.1186/2193-1801-3-158. http://dx.doi.org/10.1186/2193-1801-3-158.
AbstractIschemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12152917
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