dc.contributor.author | Bassi, Roberto | en_US |
dc.contributor.author | Vergani, Andrea | en_US |
dc.contributor.author | D’Addio, Francesca | en_US |
dc.contributor.author | Nasr, Moufida Ben | en_US |
dc.contributor.author | Mocci, Alessio | en_US |
dc.contributor.author | Rastaldi, Maria Pia | en_US |
dc.contributor.author | Ichimura, Takaharu | en_US |
dc.contributor.author | Vincent Bonventre, Joseph | en_US |
dc.contributor.author | Fiorina, Paolo | en_US |
dc.date.accessioned | 2014-05-06T16:17:38Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Bassi, Roberto, Andrea Vergani, Francesca D’Addio, Moufida Ben Nasr, Alessio Mocci, Maria Pia Rastaldi, Takaharu Ichimura, Joseph Vincent Bonventre, and Paolo Fiorina. 2014. “Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report.” SpringerPlus 3 (1): 158. doi:10.1186/2193-1801-3-158. http://dx.doi.org/10.1186/2193-1801-3-158. | en |
dc.identifier.issn | 2193-1801 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152917 | |
dc.description.abstract | Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury. | en |
dc.language.iso | en_US | en |
dc.publisher | Springer International Publishing | en |
dc.relation.isversionof | doi:10.1186/2193-1801-3-158 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979974/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Ischemia/reperfusion | en |
dc.subject | Kidney disease | en |
dc.subject | Kidney transplantation | en |
dc.subject | Radical oxygen species | en |
dc.subject | Inflammation | en |
dc.title | Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | SpringerPlus | en |
dash.depositing.author | Bassi, Roberto | en_US |
dc.date.available | 2014-05-06T16:17:38Z | |
dc.identifier.doi | 10.1186/2193-1801-3-158 | * |
dash.contributor.affiliated | Ichimura, Takaharu | |
dash.contributor.affiliated | Fiorina, Paolo | |
dash.contributor.affiliated | Bassi, Roberto | |