Zebrafish models of cerebrovascular disease

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Zebrafish models of cerebrovascular disease

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Title: Zebrafish models of cerebrovascular disease
Author: Walcott, Brian P; Peterson, Randall T

Note: Order does not necessarily reflect citation order of authors.

Citation: Walcott, Brian P., and Randall T Peterson. 2014. “Zebrafish models of cerebrovascular disease.” Journal of Cerebral Blood Flow & Metabolism 34 (4): 571-577. doi:10.1038/jcbfm.2014.27. http://dx.doi.org/10.1038/jcbfm.2014.27.
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Abstract: Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease processes, the ultimate final pathologic insult in humans is defined as a stroke, or damage to brain parenchyma. In the case of ischemic stroke, blood fails to reach its target destination whereas in hemorrhagic stroke, extravasation of blood occurs outside of the blood vessel lumen, resulting in direct damage to brain parenchyma. As these acute events can be neurologically devastating, if not fatal, development of novel therapeutics are urgently needed. The zebrafish (Danio rerio) is an attractive model for the study of cerebrovascular disease because of its morphological and physiological similarity to human cerebral vasculature, its ability to be genetically manipulated, and its fecundity allowing for large-scale, phenotype-based screens.
Published Version: doi:10.1038/jcbfm.2014.27
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982096/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152930
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