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dc.contributor.authorCoroller, Thibaud P.en_US
dc.contributor.authorMak, Raymond H.en_US
dc.contributor.authorLewis, John H.en_US
dc.contributor.authorBaldini, Elizabeth H.en_US
dc.contributor.authorChen, Aileen B.en_US
dc.contributor.authorColson, Yolonda L.en_US
dc.contributor.authorHacker, Fred L.en_US
dc.contributor.authorHermann, Gretchenen_US
dc.contributor.authorKozono, Daviden_US
dc.contributor.authorMannarino, Edwarden_US
dc.contributor.authorMolodowitch, Christinaen_US
dc.contributor.authorWee, Jon O.en_US
dc.contributor.authorSher, David J.en_US
dc.contributor.authorKilloran, Joseph H.en_US
dc.date.accessioned2014-05-06T16:17:50Z
dc.date.issued2014en_US
dc.identifier.citationCoroller, T. P., R. H. Mak, J. H. Lewis, E. H. Baldini, A. B. Chen, Y. L. Colson, F. L. Hacker, et al. 2014. “Low Incidence of Chest Wall Pain with a Risk-Adapted Lung Stereotactic Body Radiation Therapy Approach Using Three or Five Fractions Based on Chest Wall Dosimetry.” PLoS ONE 9 (4): e94859. doi:10.1371/journal.pone.0094859. http://dx.doi.org/10.1371/journal.pone.0094859.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12152940
dc.description.abstractPurpose To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) for patients receiving lung stereotactic body radiotherapy (SBRT) using treatment planning methods to minimize CW dose and a risk-adapted fractionation scheme. Methods: We reviewed data from 72 treatment plans, from 69 lung SBRT patients with at least one year of follow-up or CW toxicity, who were treated at our center between 2010 and 2013. Treatment plans were optimized to reduce CW dose and patients received a risk-adapted fractionation of 18 Gy×3 fractions (54 Gy total) if the CW V30 was less than 30 mL or 10–12 Gy×5 fractions (50–60 Gy total) otherwise. The association between CW toxicity and patient characteristics, treatment parameters and dose metrics, including biologically equivalent dose, were analyzed using logistic regression. Results: With a median follow-up of 20 months, 6 (8.3%) patients developed CW pain including three (4.2%) grade 1, two (2.8%) grade 2 and one (1.4%) grade 3. Five (6.9%) patients developed rib fractures, one of which was symptomatic. No significant associations between CW toxicity and patient and dosimetric variables were identified on univariate nor multivariate analysis. Conclusions: Optimization of treatment plans to reduce CW dose and a risk-adapted fractionation strategy of three or five fractions based on the CW V30 resulted in a low incidence of CW toxicity. Under these conditions, none of the patient characteristics or dose metrics we examined appeared to be predictive of CW pain.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0094859en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984241/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectToxicologyen
dc.subjectToxic Agentsen
dc.subjectMedicine and Health Sciencesen
dc.subjectEpidemiologyen
dc.subjectCancer Epidemiologyen
dc.subjectOncologyen
dc.subjectCancers and Neoplasmsen
dc.subjectLung and Intrathoracic Tumorsen
dc.subjectNon-Small Cell Lung Canceren
dc.subjectCancer Treatmenten
dc.subjectRadiation Therapyen
dc.subjectClinical Research Designen
dc.subjectRetrospective Studiesen
dc.titleLow Incidence of Chest Wall Pain with a Risk-Adapted Lung Stereotactic Body Radiation Therapy Approach Using Three or Five Fractions Based on Chest Wall Dosimetryen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorCoroller, Thibaud P.en_US
dc.date.available2014-05-06T16:17:50Z
dc.identifier.doi10.1371/journal.pone.0094859*
dash.authorsorderedfalse
dash.contributor.affiliatedKilloran, Joseph
dash.contributor.affiliatedCoroller, Thibaud
dash.contributor.affiliatedLewis, John H.
dash.contributor.affiliatedHacker, Fred
dash.contributor.affiliatedColson, Yolonda
dash.contributor.affiliatedWee, Jon
dash.contributor.affiliatedKozono, David
dash.contributor.affiliatedChen, Aileen
dash.contributor.affiliatedMak, Raymond
dash.contributor.affiliatedBaldini, Elizabeth


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