Modulation of Autophagy-Like Processes by Tumor Viruses
Citation
Mack, Hildegard I. D., and Karl Munger. 2012. “Modulation of Autophagy-Like Processes by Tumor Viruses.” Cells 1 (3): 204-247. doi:10.3390/cells1030204. http://dx.doi.org/10.3390/cells1030204.Abstract
Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases, including those caused by viral infection. Many viruses have evolved strategies to directly interfere with autophagy, presumably to facilitate their replication or to escape immune detection. However, in some cases, modulation of autophagy appears to be a consequence of the virus disturbing the cell’s metabolic signaling networks. Here, we summarize recent advances in research at the interface of autophagy and viral infection, paying special attention to strategies that human tumor viruses have evolved.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901111/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152942
Collections
- HMS Scholarly Articles [18278]
Contact administrator regarding this item (to report mistakes or request changes)