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dc.contributor.authorMcGlinchey, Regina E.en_US
dc.contributor.authorFortier, Catherine B.en_US
dc.contributor.authorVenne, Jonathan R.en_US
dc.contributor.authorMaksimovskiy, Arkadiy L.en_US
dc.contributor.authorMilberg, William P.en_US
dc.date.accessioned2014-05-06T16:17:57Z
dc.date.issued2014en_US
dc.identifier.citationMcGlinchey, Regina E., Catherine B. Fortier, Jonathan R. Venne, Arkadiy L. Maksimovskiy, and William P. Milberg. 2014. “Effects of OEF/OIF-Related Physical and Emotional Co-Morbidities on Associative Learning: Concurrent Delay and Trace Eyeblink Classical Conditioning.” International Journal of Environmental Research and Public Health 11 (3): 3046-3073. doi:10.3390/ijerph110303046. http://dx.doi.org/10.3390/ijerph110303046.en
dc.identifier.issn1661-7827en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12152952
dc.description.abstractThis study examined the performance of veterans and active duty personnel who served in Operation Enduring Freedom and/or Operation Iraqi Freedom (OEF/OIF) on a basic associative learning task. Eighty-eight individuals participated in this study. All received a comprehensive clinical evaluation to determine the presence and severity of posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). The eyeblink conditioning task was composed of randomly intermixed delay and trace conditioned stimulus (CS) and unconditioned stimulus (US) pairs (acquisition) followed by a series of CS only trials (extinction). Results revealed that those with a clinical diagnosis of PTSD or a diagnosis of PTSD with comorbid mTBI acquired delay and trace conditioned responses (CRs) to levels and at rates similar to a deployed control group, thus suggesting intact basic associative learning. Differential extinction impairment was observed in the two clinical groups. Acquisition of CRs for both delay and trace conditioning, as well as extinction of trace CRs, was associated with alcoholic behavior across all participants. These findings help characterize the learning and memory function of individuals with PTSD and mTBI from OEF/OIF and raise the alarming possibility that the use of alcohol in this group may lead to more significant cognitive dysfunction.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/ijerph110303046en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987020/pdf/en
dash.licenseLAAen_US
dc.subjectposttraumatic stress disorderen
dc.subjectmild traumatic brain injuryen
dc.subjectalcoholen
dc.titleEffects of OEF/OIF-Related Physical and Emotional Co-Morbidities on Associative Learning: Concurrent Delay and Trace Eyeblink Classical Conditioningen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalInternational Journal of Environmental Research and Public Healthen
dash.depositing.authorMcGlinchey, Regina E.en_US
dc.date.available2014-05-06T16:17:57Z
dc.identifier.doi10.3390/ijerph110303046*
dash.contributor.affiliatedFortier, Catherine
dash.contributor.affiliatedMilberg, William
dash.contributor.affiliatedMcGlinchey, Regina


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