Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine

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Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine

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Title: Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
Author: Moulton, Eric A.; Becerra, Lino; Johnson, Adriana; Burstein, Rami; Borsook, David

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Citation: Moulton, Eric A., Lino Becerra, Adriana Johnson, Rami Burstein, and David Borsook. 2014. “Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine.” PLoS ONE 9 (4): e95508. doi:10.1371/journal.pone.0095508. http://dx.doi.org/10.1371/journal.pone.0095508.
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Abstract: The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine functional connectivity (FC) changes between the hypothalamus and the rest of the brain in migraine patients vs. control subjects. This study uses fMRI (functional magnetic resonance imaging) to acquire resting state scans in 12 interictal migraine patients and 12 healthy matched controls. Hypothalamic connectivity seeds were anatomically defined based on high-resolution structural scans, and FC was assessed in the resting state scans. Migraine patients had increased hypothalamic FC with a number of brain regions involved in regulation of autonomic functions, including the locus coeruleus, caudate, parahippocampal gyrus, cerebellum, and the temporal pole. Stronger functional connections between the hypothalamus and brain areas that regulate sympathetic and parasympathetic functions may explain some of the hypothalamic-mediated autonomic symptoms that accompany or precede migraine attacks.
Published Version: doi:10.1371/journal.pone.0095508
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990690/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152966
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