dc.contributor.author | Liu, Shuang | en_US |
dc.contributor.author | An, Jie | en_US |
dc.contributor.author | Lin, Jianhong | en_US |
dc.contributor.author | Liu, Yanli | en_US |
dc.contributor.author | Bao, Lidao | en_US |
dc.contributor.author | Zhang, Wen | en_US |
dc.contributor.author | Zhao, Jian-Jun | en_US |
dc.date.accessioned | 2014-05-06T16:18:27Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Liu, Shuang, Jie An, Jianhong Lin, Yanli Liu, Lidao Bao, Wen Zhang, and Jian-Jun Zhao. 2014. “Single Nucleotide Polymorphisms of MicroRNA Processing Machinery Genes and Outcome of Hepatocellular Carcinoma.” PLoS ONE 9 (3): e92791. doi:10.1371/journal.pone.0092791. http://dx.doi.org/10.1371/journal.pone.0092791. | en |
dc.identifier.issn | 1932-6203 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12153014 | |
dc.description.abstract | MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome. Among the 6 SNPs, only the A/A genotype of rs11077 located in XPO5 3′UTR was identified to associated independently with worse survival in HCC patients by multivariate analysis with relative risk, 0.395; 95% CI, 0.167–0.933; p = 0.034. This is the first study reporting that polymorphisms related to miRSNPs have prognostic value in hepatocellular carcinoma and identify the A/A genotype of rs11077 SNP site located in XPO5 3′UTR can help to predict worse prognosis in patients. | en |
dc.language.iso | en_US | en |
dc.publisher | Public Library of Science | en |
dc.relation.isversionof | doi:10.1371/journal.pone.0092791 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968016/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Biology and life sciences | en |
dc.subject | Biochemistry | en |
dc.subject | RNA | en |
dc.subject | RNA processing | en |
dc.subject | Cell Biology | en |
dc.subject | Molecular Cell Biology | en |
dc.subject | Evolutionary Biology | en |
dc.subject | Population Genetics | en |
dc.subject | Genetic Polymorphism | en |
dc.subject | Genetics | en |
dc.subject | Human Genetics | en |
dc.subject | Genetic Association Studies | en |
dc.subject | Cancer Genetics | en |
dc.subject | Gene Expression | en |
dc.subject | Population Biology | en |
dc.subject | Medicine and Health Sciences | en |
dc.subject | Clinical Genetics | en |
dc.subject | Epidemiology | en |
dc.subject | Cancer Epidemiology | en |
dc.subject | Gastroenterology and Hepatology | en |
dc.subject | Liver Diseases | en |
dc.subject | Hepatocellular Carcinoma | en |
dc.subject | Oncology | en |
dc.subject | Cancer Risk Factors | en |
dc.subject | Genetic Causes of Cancer | en |
dc.subject | Cancers and Neoplasms | en |
dc.subject | Gastrointestinal Tumors | en |
dc.title | Single Nucleotide Polymorphisms of MicroRNA Processing Machinery Genes and Outcome of Hepatocellular Carcinoma | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | PLoS ONE | en |
dash.depositing.author | Lin, Jianhong | en_US |
dc.date.available | 2014-05-06T16:18:27Z | |
dc.identifier.doi | 10.1371/journal.pone.0092791 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Lin, Jianhong | |