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dc.contributor.authorBalskus, Emily Patricia
dc.contributor.authorWalsh, Christopher T.
dc.date.accessioned2014-05-08T14:52:16Z
dc.date.issued2008
dc.identifier.citationBalskus, Emily P., and Christopher T. Walsh. 2008. “Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin.” Journal of the American Chemical Society 130 (46) (November 19): 15260–15261.en_US
dc.identifier.issn0002-7863en_US
dc.identifier.issn1520-5126en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12153245
dc.description.abstractThe cyanobacterial natural product scytonemin (1) functions as a sunscreen, absorbing harmful UV-A radiation. Using information from a recently identified gene cluster, we propose a biosynthetic route to this pigment. We also report the characterization of two enzymes, NpR1275 and NpR1276, which are involved in the initial stages of this pathway. A regioselective acyloin reaction between indole-3-pyruvic acid (4) and p-hydroxyphenylpyruvic acid (5) is a key step in assembling the carbon framework of a proposed monomeric scytonemin precursor (2).en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofdoi:10.1021/ja807192uen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631159/en_US
dash.licenseOAP
dc.titleInvestigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytoneminen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJournal of the American Chemical Societyen_US
dash.depositing.authorBalskus, Emily Patricia
dc.date.available2014-05-08T14:52:16Z
dash.affiliation.otherDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolen_US
dc.identifier.doi10.1021/ja807192u*
dash.contributor.affiliatedWalsh, Christopher
dash.contributor.affiliatedBalskus, Emily


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