The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition
Access StatusFull text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.
MetadataShow full item record
CitationIlter, Didem. 2014. The Role of ERK2 in Regulating Epithelial-Mesenchymal Transition. Doctoral dissertation, Harvard University.
AbstractEpithelial-mesenchymal transition (EMT) is a fundamental developmental program, which is believed to be reactivated during the progression of in situ carcinoma to aggressive metastatic cancers. Ras-ERK pathway has been shown to play a crucial role in EMT. We have previously shown that ERK2, but not ERK1, is necessary for RasV12-induced EMT and overexpression of ERK2 is sufficient to promote EMT. ERK2 promotes EMT by regulating several factors, including the upregulation of transcription factors ZEB1/2. ZEB1/2 repress expression of E-cadherin, which is necessary for polar epithelial tissue formations.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274122
- FAS Theses and Dissertations