dc.contributor.advisor | Wirth, Dyann F. | |
dc.contributor.author | Herman, Jonathan David | |
dc.date.accessioned | 2014-06-06T19:18:41Z | |
dash.embargo.terms | 2015-06-04 | en_US |
dash.embargo.terms | 2015-06-04 | |
dc.date.issued | 2014-06-06 | |
dc.date.submitted | 2014 | |
dc.identifier.citation | Herman, Jonathan David. 2014. Halofuginone: A Story of How Target Identification of an Ancient Chinese Medicine and Multi-Step Evolution Informs Malaria Drug Discovery. Doctoral dissertation, Harvard University. | en_US |
dc.identifier.other | http://dissertations.umi.com/gsas.harvard:11540 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274328 | |
dc.description.abstract | Malaria is a treatable communicable disease yet remains a common cause of death and disease especially among pregnant women and children. Most of malaria's worldwide burden disproportionately lies in Southeast Asia and Sub-Saharan Africa. Western medicine's 100+ year history of combating Plasmodium falciparum has taught us that the global population of malaria parasites has a unique and dangerous ability to rapidly evolve and spread drug resistance. Recently it was documented that resistance to the first-line antimalarial artemisinin may be developing in Southeast Asia. | en_US |
dc.language.iso | en_US | en_US |
dash.license | LAA | |
dc.subject | Parasitology | en_US |
dc.subject | Biology | en_US |
dc.subject | Public health | en_US |
dc.subject | drug resistance | en_US |
dc.subject | evolution | en_US |
dc.subject | halofuginone | en_US |
dc.subject | malaria | en_US |
dc.subject | non-genetic adaptation | en_US |
dc.subject | tRNA synthetase | en_US |
dc.title | Halofuginone: A Story of How Target Identification of an Ancient Chinese Medicine and Multi-Step Evolution Informs Malaria Drug Discovery | en_US |
dc.type | Thesis or Dissertation | en_US |
dash.depositing.author | Herman, Jonathan David | |
dc.date.available | 2015-06-04T07:30:49Z | |
thesis.degree.date | 2014 | en_US |
thesis.degree.discipline | Biological and Biomedical Sciences | en_US |
thesis.degree.grantor | Harvard University | en_US |
thesis.degree.level | doctoral | en_US |
thesis.degree.name | Ph.D. | en_US |
dc.contributor.committeeMember | Gray, Nathanael | en_US |
dc.contributor.committeeMember | Garraway, Levi | en_US |
dc.contributor.committeeMember | Duraisingh, Manoj | en_US |
dc.contributor.committeeMember | Winzeler, Elizabeth | en_US |
dash.contributor.affiliated | Herman, Jonathan D | |