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dc.contributor.advisorWirth, Dyann F.
dc.contributor.authorHerman, Jonathan David
dc.date.accessioned2014-06-06T19:18:41Z
dash.embargo.terms2015-06-04en_US
dash.embargo.terms2015-06-04
dc.date.issued2014-06-06
dc.date.submitted2014
dc.identifier.citationHerman, Jonathan David. 2014. Halofuginone: A Story of How Target Identification of an Ancient Chinese Medicine and Multi-Step Evolution Informs Malaria Drug Discovery. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11540en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274328
dc.description.abstractMalaria is a treatable communicable disease yet remains a common cause of death and disease especially among pregnant women and children. Most of malaria's worldwide burden disproportionately lies in Southeast Asia and Sub-Saharan Africa. Western medicine's 100+ year history of combating Plasmodium falciparum has taught us that the global population of malaria parasites has a unique and dangerous ability to rapidly evolve and spread drug resistance. Recently it was documented that resistance to the first-line antimalarial artemisinin may be developing in Southeast Asia.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectParasitologyen_US
dc.subjectBiologyen_US
dc.subjectPublic healthen_US
dc.subjectdrug resistanceen_US
dc.subjectevolutionen_US
dc.subjecthalofuginoneen_US
dc.subjectmalariaen_US
dc.subjectnon-genetic adaptationen_US
dc.subjecttRNA synthetaseen_US
dc.titleHalofuginone: A Story of How Target Identification of an Ancient Chinese Medicine and Multi-Step Evolution Informs Malaria Drug Discoveryen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorHerman, Jonathan David
dc.date.available2015-06-04T07:30:49Z
thesis.degree.date2014en_US
thesis.degree.disciplineBiological and Biomedical Sciencesen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberGray, Nathanaelen_US
dc.contributor.committeeMemberGarraway, Levien_US
dc.contributor.committeeMemberDuraisingh, Manojen_US
dc.contributor.committeeMemberWinzeler, Elizabethen_US
dash.contributor.affiliatedHerman, Jonathan D


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