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dc.contributor.advisorChurch, George McDonald
dc.contributor.advisorZhang, Feng
dc.contributor.authorCong, Le
dc.date.accessioned2014-06-06T19:20:12Z
dc.date.issued2014-06-06
dc.date.submitted2013
dc.identifier.citationCong, Le. 2014. Genome Engineering Technology and Its Application in Mammalian Cells. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11309en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274330
dc.description.abstractThe advancement of high-throughput, large-scale biochemical, biophysical, and genetic technologies has enabled the generation of massive amounts of biological data and allowed us to synthesize various types of biomaterial for engineering purposes. This enabled improved observational methodologies for us to navigate and locate, with unprecedented resolution, the potential factors and connections that may contribute to biological and biomedical processes. Nonetheless, it leaves us with the increasing demand to validate these observations to elucidate the actual causal mechanisms in biology and medicine. Due to the lack of powerful and precise tools to manipulate biological systems in mammalian cells, these efforts have not been able to progress at an adequate pace.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectMolecular biologyen_US
dc.subjectGeneticsen_US
dc.subjectBioengineeringen_US
dc.subjectCas9en_US
dc.subjectCRISPRen_US
dc.subjectGenome Engineeringen_US
dc.subjectMolecular Biologyen_US
dc.subjectTAL effectoren_US
dc.titleGenome Engineering Technology and Its Application in Mammalian Cellsen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorCong, Le
dc.date.available2014-06-06T19:20:12Z
thesis.degree.date2014en_US
thesis.degree.disciplineBiology: Medical Sciences, Division ofen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberZhang, Yien_US
dc.contributor.committeeMemberHyman, Stevenen_US
dc.contributor.committeeMemberWong, Wilsonen_US
dc.contributor.committeeMemberCepko, Constanceen_US
dash.contributor.affiliatedCong, L


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