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dc.contributor.advisorChurch, George McDonald
dc.contributor.authorMarblestone, Adam Henry
dc.date.accessioned2014-06-06T20:18:25Z
dc.date.issued2014-06-06
dc.date.submitted2014
dc.identifier.citationMarblestone, Adam Henry. 2014. Designing Scalable Biological Interfaces. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11381en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274513
dc.description.abstractThis thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but also extends to other problems including genomic editing and nanoscale spatial control. Its main contributions include analysis of the physical limits of large-scale neural recording, experimental development of a screening platform for ion-dependent molecular recording devices, characterization of the design space for molecularly-annotated neural connectomics, and new designs for high-speed genome engineering and bio-nano-fabrication. Articulating governing principles and roadmaps for these domains has contributed to the initiation of multi-institutional projects that are strategically targeted towards scalability.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectBiophysicsen_US
dc.subjectNeurosciencesen_US
dc.subjectBiomedical engineeringen_US
dc.titleDesigning Scalable Biological Interfacesen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorMarblestone, Adam Henry
dc.date.available2014-06-06T20:18:25Z
thesis.degree.date2014en_US
thesis.degree.disciplineBiophysicsen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberBoyden, Edwarden_US
dc.contributor.committeeMemberJacobson, Josephen_US
dc.contributor.committeeMemberYin, Pengen_US
dc.contributor.committeeMemberHogle, Jamesen_US
dash.contributor.affiliatedMarblestone, Adam Henry


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