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dc.contributor.advisorParker, Kevin Kit
dc.contributor.authorHorton, Renita Elillian
dc.date.accessioned2014-06-06T20:43:06Z
dash.embargo.terms2016-06-04en_US
dc.date.issued2014-06-06
dc.date.submitted2014
dc.identifier.citationHorton, Renita Elillian. 2014. The Role of Microenvironmental Cues in Cardiomyogenesis and Pathogenesis. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11569en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274542
dc.description.abstractThe cellular microenvironment consists of soluble and insoluble factors that provide signals that dictate cell behavior and cell fate. Limited characterization has hindered our ability to mimic the physiological or pathophysiological environment. While stem cells have vast promise in the areas of regenerative medicine and disease therapy, harnessing this potential remains elusive due to our limited understanding of differentiation mechanisms. Similarly, many in vitro cardiac disease models lack the critical structure- function relationships of healthy and diseased cardiac tissue. The goal of this work is to induce cardiomyogenesis and pathogenesis in vitro by recapitulating features of the native microenvironment during development and disease.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dash.licenseMETA_ONLY
dc.subjectBiomedical engineeringen_US
dc.subjectcardiomyocyteen_US
dc.subjecthypoxiaen_US
dc.subjectmicroenvironmenten_US
dc.subjectstem cellsen_US
dc.titleThe Role of Microenvironmental Cues in Cardiomyogenesis and Pathogenesisen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorHorton, Renita Elillian
dash.embargo.until10000-01-01
thesis.degree.date2014en_US
thesis.degree.disciplineEngineering Sciencesen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberMooney, Daviden_US
dc.contributor.committeeMemberWestervelt, Roberten_US
dash.contributor.affiliatedHorton, Renita E.


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