Distortions in Genealogies due to Purifying Selection

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Distortions in Genealogies due to Purifying Selection

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dc.contributor.advisor Desai, Michael Manish
dc.contributor.author Nicolaisen, Lauren Elisabeth
dc.date.accessioned 2014-06-06T21:03:52Z
dc.date.issued 2014-06-06
dc.date.submitted 2014
dc.identifier.citation Nicolaisen, Lauren Elisabeth. 2014. Distortions in Genealogies due to Purifying Selection. Doctoral dissertation, Harvard University. en_US
dc.identifier.other http://dissertations.umi.com/gsas.harvard:11357 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274562
dc.description.abstract As deleterious variants continually arise in a population, they tend to be purged via purifying selection, leading to distortions in the shapes of genealogies relative to neutral expectations. In recent years, a mounting body of evidence has arisen suggesting that this can have significant implications for the patterns of diversity seen in natural populations. However, existing theory has not yet fully characterized the effects of these distortions on the structure of genealogies. The focus of this thesis is on exploring this gap, and developing an analytical description of the distortions that arise in genealogies due to purifying selection. en_US
dc.description.sponsorship Physics en_US
dc.language.iso en_US en_US
dash.license LAA
dc.subject Physics en_US
dc.subject Coalescent en_US
dc.subject Genealogies en_US
dc.subject Population Genetics en_US
dc.subject Purifying Selection en_US
dc.title Distortions in Genealogies due to Purifying Selection en_US
dc.type Thesis or Dissertation en_US
dash.depositing.author Nicolaisen, Lauren Elisabeth
dc.date.available 2014-06-06T21:03:52Z
thesis.degree.date 2014 en_US
thesis.degree.discipline Physics en_US
thesis.degree.grantor Harvard University en_US
thesis.degree.level doctoral en_US
thesis.degree.name Ph.D. en_US
dc.contributor.committeeMember Nelson, David en_US
dc.contributor.committeeMember Wakeley, John en_US

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