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dc.contributor.advisorDesai, Michael Manish
dc.contributor.authorNicolaisen, Lauren Elisabeth
dc.date.accessioned2014-06-06T21:03:52Z
dc.date.issued2014-06-06
dc.date.submitted2014
dc.identifier.citationNicolaisen, Lauren Elisabeth. 2014. Distortions in Genealogies due to Purifying Selection. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11357en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274562
dc.description.abstractAs deleterious variants continually arise in a population, they tend to be purged via purifying selection, leading to distortions in the shapes of genealogies relative to neutral expectations. In recent years, a mounting body of evidence has arisen suggesting that this can have significant implications for the patterns of diversity seen in natural populations. However, existing theory has not yet fully characterized the effects of these distortions on the structure of genealogies. The focus of this thesis is on exploring this gap, and developing an analytical description of the distortions that arise in genealogies due to purifying selection.en_US
dc.description.sponsorshipPhysicsen_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectPhysicsen_US
dc.subjectCoalescenten_US
dc.subjectGenealogiesen_US
dc.subjectPopulation Geneticsen_US
dc.subjectPurifying Selectionen_US
dc.titleDistortions in Genealogies due to Purifying Selectionen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorNicolaisen, Lauren Elisabeth
dc.date.available2014-06-06T21:03:52Z
thesis.degree.date2014en_US
thesis.degree.disciplinePhysicsen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberNelson, Daviden_US
dc.contributor.committeeMemberWakeley, Johnen_US
dash.contributor.affiliatedNicolaisen, Lauren Elisabeth


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