New insights into BRCA1 function and its role in cancer development

Hill, Sarah James

Citation

Hill, Sarah James. 2014. New insights into BRCA1 function and its role in cancer development. Doctoral dissertation, Harvard University.

Abstract

BRCA1 is a breast and ovarian tumor suppressor. The role of BRCA1 in the repair of double strand DNA breaks by homologous recombination [HR] is its best understood function and the function most often implicated in BRCA1 breast cancer suppression. However, BRCA1 has less well defined roles in multiple other molecular processes.

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