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dc.contributor.advisorFarzan, Michael
dc.contributor.authorGardner, Matthew Ryan
dc.date.accessioned2014-06-06T21:18:07Z
dc.date.issued2014-06-06
dc.date.submitted2014
dc.identifier.citationGardner, Matthew Ryan. 2014. Targeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoprotein. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11644en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12274576
dc.description.abstractThe HIV-1 envelope glycoprotein, Env, facilitates the translocation of the viral capsid across the cellular membrane. Env is a trimer of hetero-dimers composed of a gp120 subunit and gp41 transmembrane protein. The gp120 subunit binds the primary receptor, CD4, leading to conformational changes of Env that then promote binding to the coreceptor, principally CCR5 or CXCR4. As the sole protein on the surface of the virion, Env is under continuous pressure from the host's antibody response. Two classes of antibodies target the highly conserved receptor-binding sites of gp120: CD4-binding site (CD4bs) and CD4-induced (CD4i) antibodies.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectVirologyen_US
dc.subjectbroadly neutralizing antibodiesen_US
dc.subjectCD4i antibodiesen_US
dc.subjecteCD4-Igen_US
dc.subjectHIV-1 entryen_US
dc.subjectHIV-1 envelope glycoproteinen_US
dc.titleTargeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoproteinen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorGardner, Matthew Ryan
dc.date.available2014-06-06T21:18:07Z
thesis.degree.date2014en_US
thesis.degree.disciplineBiology: Medical Sciences, Division ofen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberGabuzda, Danaen_US
dc.contributor.committeeMemberBarouch, Danen_US
dc.contributor.committeeMemberKuritzkes, Danielen_US
dc.contributor.committeeMemberSagar, Manishen_US
dash.contributor.affiliatedGardner, Matthew Ryan


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