Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis

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Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis

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Title: Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis
Author: Hall, Jessica Ann
Citation: Hall, Jessica Ann. 2014. Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis. Doctoral dissertation, Harvard University.
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Abstract: Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, multi-organ effort that integrates hormonal signals with transcriptional regulatory networks. When these relationships are altered, as with over-nutrition and insulin resistance, metabolic disease ensues. Here, I present data concerning two distinct transcriptional pathways--one for thyroid hormone (TH) and one for insulin--that confer hormone responsiveness on metabolic gene programs that preserve energy homeostasis.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274577
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