dc.contributor.advisor | Puigserver, Pere Puigserver | |
dc.contributor.author | Hall, Jessica Ann | |
dc.date.accessioned | 2014-06-06T21:18:43Z | |
dc.date.issued | 2014-06-06 | |
dc.date.submitted | 2014 | |
dc.identifier.citation | Hall, Jessica Ann. 2014. Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis. Doctoral dissertation, Harvard University. | en_US |
dc.identifier.other | http://dissertations.umi.com/gsas.harvard:11663 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274577 | |
dc.description.abstract | Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, multi-organ effort that integrates hormonal signals with transcriptional regulatory networks. When these relationships are altered, as with over-nutrition and insulin resistance, metabolic disease ensues. Here, I present data concerning two distinct transcriptional pathways--one for thyroid hormone (TH) and one for insulin--that confer hormone responsiveness on metabolic gene programs that preserve energy homeostasis. | en_US |
dc.language.iso | en_US | en_US |
dash.license | LAA | |
dc.subject | Biology | en_US |
dc.subject | Cellular biology | en_US |
dc.subject | Molecular biology | en_US |
dc.subject | brown adipose tissue | en_US |
dc.subject | glucose metabolism | en_US |
dc.subject | insulin | en_US |
dc.subject | thermogenesis | en_US |
dc.subject | thyroid hormone | en_US |
dc.title | Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis | en_US |
dc.type | Thesis or Dissertation | en_US |
dash.depositing.author | Hall, Jessica Ann | |
dc.date.available | 2014-06-06T21:18:43Z | |
thesis.degree.date | 2014 | en_US |
thesis.degree.discipline | Biology: Medical Sciences, Division of | en_US |
thesis.degree.grantor | Harvard University | en_US |
thesis.degree.level | doctoral | en_US |
thesis.degree.name | Ph.D. | en_US |
dc.contributor.committeeMember | Maratos-Flier, Eleftheria | en_US |
dc.contributor.committeeMember | Banks, Alexander | en_US |
dc.contributor.committeeMember | Ruderman, Neil | en_US |
dash.contributor.affiliated | Hall, Jessica | |