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dc.contributor.authorRubin, Daniel James
dc.contributor.authorNia, Hadi T.
dc.contributor.authorDesire, Thierry
dc.contributor.authorNguyen, Peter Q
dc.contributor.authorGevelber, Michael
dc.contributor.authorOrtiz, Christine
dc.contributor.authorJoshi, Neel S.
dc.date.accessioned2014-06-17T16:07:00Z
dc.date.issued2013
dc.identifier.citationRubin, Daniel J., Hadi T. Nia, Thierry Desire, Peter Q. Nguyen, Michael Gevelber, Christine Ortiz, and Neel S. Joshi. 2013. Mechanical Reinforcement of Polymeric Fibers through Peptide Nanotube Incorporation. Biomacromolecules 14, no. 10: 3370–3375.en_US
dc.identifier.issn1525-7797en_US
dc.identifier.issn1526-4602en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12330893
dc.description.abstractHigh aspect ratio nanotubular assemblies can be effective fillers in mechanically reinforced composite materials. However, most existing nanotubes used for structural purposes are limited in their range of mechanical, chemical, and biological properties. We demonstrate an alternative approach to mechanical reinforcement of polymeric systems by incorporating synthetic d,l-cyclic peptide nanotube bundles as a structural filler in electrospun poly d-, l-lactic acid fibers. The nanotube bundles self-assemble through dynamic hydrogen bonding from synthetic cyclic peptides to yield structures whose dimensions can be altered based on processing conditions, and can be up to hundreds of micrometers long and several hundred nanometers wide. With 8 wt % peptide loading, the composite fibers are >5-fold stiffer than fibers composed of the polymer alone, according to atomic force microscopy-based indentation experiments. This represents a new use for self-assembling cyclic peptides as a load-bearing component in biodegradable composite materials.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofdoi:10.1021/bm4008293en_US
dc.relation.hasversionhttp://web.mit.edu/cortiz/www/Joshi2013.pdfen_US
dash.licenseOAP
dc.subjectCyclic peptidesen_US
dc.subjectnanofibersen_US
dc.subjectmechanical reinforcementen_US
dc.subjectsupramolecularen_US
dc.titleMechanical Reinforcement of Polymeric Fibers through Peptide Nanotube Incorporationen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBiomacromoleculesen_US
dash.depositing.authorJoshi, Neel S.
dc.date.available2014-06-17T16:07:00Z
dc.identifier.doi10.1021/bm4008293*
workflow.legacycommentsFAR 2014en_US
dash.contributor.affiliatedRubin, Daniel James
dash.contributor.affiliatedNguyen, Peter
dash.contributor.affiliatedJoshi, Neel


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