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dc.contributor.authorLiang, Theresa
dc.contributor.authorNeumann, Constanze Nicole
dc.contributor.authorRitter, Tobias
dc.date.accessioned2014-06-18T18:57:24Z
dc.date.issued2013
dc.identifier.citationLiang, Theresa, Constanze N. Neumann, and Tobias Ritter. 2013. Introduction of Fluorine and Fluorine-Containing Functional Groups. Angewandte Chemie International Edition 52, no. 32: 8214–8264.en_US
dc.identifier.issn1433-7851en_US
dc.identifier.issn1521-3773en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12336403
dc.description.abstractOver the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation of the parent C[BOND]F bond, primarily as a consequence of the high hydration energy of fluoride, strong metal—fluorine bonds, and highly polarized bonds to fluorine. Most fluorination reactions still lack generality, predictability, and cost-efficiency. Despite all current limitations, modern fluorination methods have made fluorinated molecules more readily available than ever before and have begun to have an impact on research areas that do not require large amounts of material, such as drug discovery and positron emission tomography. This Review gives a brief summary of conventional fluorination reactions, including those reactions that introduce fluorinated functional groups, and focuses on modern developments in the field.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherWiley-VCH Verlag Berlinen_US
dc.relation.isversionofdoi:10.1002/anie.201206566en_US
dc.relation.hasversionhttp://rittergroup.org/pdf/2013-8214-ACIE.pdfen_US
dash.licenseOAP
dc.subjectfluorineen_US
dc.subjecthomogeneous catalysisen_US
dc.subjecttransition metalsen_US
dc.subjecttrifluoromethylationen_US
dc.subjectC-H functionalizationen_US
dc.titleIntroduction of Fluorine and Fluorine-Containing Functional Groupsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalAngewandte Chemie International Editionen_US
dash.depositing.authorRitter, Tobias
dc.date.available2014-06-18T18:57:24Z
dc.identifier.doi10.1002/anie.201206566*
workflow.legacycommentsFAR 2014en_US
dash.contributor.affiliatedLiang, Theresa
dash.contributor.affiliatedNeumann, Constanze N.
dash.contributor.affiliatedRitter, Tobias


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