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dc.contributor.authorKang, DongKyun
dc.contributor.authorMartinez, Ramses V.
dc.contributor.authorWhitesides, George McClelland
dc.contributor.authorTearney, Guillermo James
dc.date.accessioned2014-07-03T14:51:08Z
dc.date.issued2013
dc.identifier.citationKang, Dongkyun, Ramses V. Martinez, George M. Whitesides, and Guillermo J. Tearney. 2013. “Miniature Grating for Spectrally-Encoded Endoscopy.” Lab Chip 13 (9): 1810.en_US
dc.identifier.issn1473-0197en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12388524
dc.description.abstractSpectrally-encoded endoscopy (SEE) is an ultraminiature endoscopy technology that acquires high-definition images of internal organs through a sub-mm endoscopic probe. In SEE, a grating at the tip of the imaging optics diffracts the broadband light into multiple beams, where each beam with a distinctive wavelength is illuminated on a unique transverse location of the tissue. By encoding one transverse coordinate with the wavelength, SEE can image a line of the tissue at a time without using any beam scanning devices. This feature of the SEE technology allows the SEE probe to be miniaturized to sub-mm dimensions. While previous studies have shown that SEE has the potential to be utilized for various clinical imaging applications, the translation of SEE for medicine has been hampered by challenges in fabricating the miniature grating inherent to SEE probes. This paper describes a new fabrication method for SEE probes. The new method uses a soft lithographic approach to pattern a high-aspect-ratio grating at the tip of the miniature imaging optics. Using this technique, we have constructed a 500 μm-diameter SEE probe. The miniature grating at the tip of the probe had a measured diffraction efficiency of 75%. The new SEE probe was used to image a human finger and formalin fixed mouse embryos, demonstrating the capability of this device to visualize key anatomic features of tissues with high image contrast. In addition to providing high quality imaging SEE optics, the soft lithography method allows cost-effective and reliable fabrication of these miniature endoscopes, which will facilitate the clinical translation of SEE technology.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofdoi:10.1039/c3lc50076den_US
dash.licenseOAP
dc.titleMiniature grating for spectrally-encoded endoscopyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalLab on a Chipen_US
dash.depositing.authorWhitesides, George McClelland
dc.date.available2014-07-03T14:51:08Z
dc.identifier.doi10.1039/c3lc50076d*
workflow.legacycommentsFAR 2014en_US
dash.contributor.affiliatedKang, Dongkyun
dash.contributor.affiliatedTearney, Guillermo
dash.contributor.affiliatedWhitesides, George
dc.identifier.orcid0000-0001-9451-2442


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