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dc.contributor.authorBhuiyan, Saruaren_US
dc.contributor.authorSayeed, Abuen_US
dc.contributor.authorKhanam, Farhanaen_US
dc.contributor.authorLeung, Daniel T.en_US
dc.contributor.authorRahman Bhuiyan, Taufiquren_US
dc.contributor.authorSheikh, Alaullahen_US
dc.contributor.authorSalma, Ummeen_US
dc.contributor.authorLaRocque, Regina C.en_US
dc.contributor.authorHarris, Jason B.en_US
dc.contributor.authorPacek, Marcinen_US
dc.contributor.authorCalderwood, Stephen B.en_US
dc.contributor.authorLaBaer, Joshuaen_US
dc.contributor.authorRyan, Edward T.en_US
dc.contributor.authorQadri, Firdausien_US
dc.contributor.authorCharles, Richelle C.en_US
dc.date.accessioned2014-07-07T17:01:43Z
dc.date.issued2014en_US
dc.identifier.citationBhuiyan, S., A. Sayeed, F. Khanam, D. T. Leung, T. Rahman Bhuiyan, A. Sheikh, U. Salma, et al. 2014. “Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh.” The American Journal of Tropical Medicine and Hygiene 90 (6): 1024-1030. doi:10.4269/ajtmh.13-0261. http://dx.doi.org/10.4269/ajtmh.13-0261.en
dc.identifier.issn0002-9637en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406547
dc.description.abstractWe assessed interferon-gamma (IFN-γ) responses via enzyme-linked immunosorbent spot (ELISPOT) to a number of S. Typhi antigens in samples from humans with S. Typhi bacteremia and typhoid fever in Bangladesh. Compared with responses in healthy endemic zone controls, there were significantly increased IFN-γ responses at the time of clinical presentation (acute phase) and at convalescence 14–28 days later. The majority (80–90%) of IFN-γ expressing T cells were CD4+. We observed a significant increase in interleukin-17 (IL-17) positive CD4 + T cells at convalescent versus acute stage of infection using an intracellular cytokine staining assay. We also found that stimulated peripheral blood mononuclear cells (PBMCs) produced significantly increased levels of a number of cytokines at the convalescent versus acute phase of infection, including IFN-γ, MIP-1β, sCD40L, TNF-β, IL-13, and IL-9. These results suggest that S. Typhi antigens induce a predominantly Th1 response, but that elevations in other cytokines may be modulatory.en
dc.language.isoen_USen
dc.publisherThe American Society of Tropical Medicine and Hygieneen
dc.relation.isversionofdoi:10.4269/ajtmh.13-0261en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047724/pdf/en
dash.licenseLAAen_US
dc.titleCellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladeshen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalThe American Journal of Tropical Medicine and Hygieneen
dash.depositing.authorLeung, Daniel T.en_US
dc.date.available2014-07-07T17:01:43Z
dc.identifier.doi10.4269/ajtmh.13-0261*
dash.authorsorderedfalse
dash.contributor.affiliatedLeung, Daniel T.
dash.contributor.affiliatedCalderwood, Stephen
dash.contributor.affiliatedCharles, Richelle
dash.contributor.affiliatedLarocque, Regina
dash.contributor.affiliatedHarris, Jason
dash.contributor.affiliatedRyan, Edward


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