Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study

DSpace/Manakin Repository

Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study

Citable link to this page

 

 
Title: Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study
Author: Lepeule, Johanna; Bind, Marie-Abele Catherine; Baccarelli, Andrea A.; Koutrakis, Petros; Tarantini, Letizia; Litonjua, Augusto; Sparrow, David; Vokonas, Pantel; Schwartz, Joel D.

Note: Order does not necessarily reflect citation order of authors.

Citation: Lepeule, Johanna, Marie-Abele Catherine Bind, Andrea A. Baccarelli, Petros Koutrakis, Letizia Tarantini, Augusto Litonjua, David Sparrow, Pantel Vokonas, and Joel D. Schwartz. 2014. “Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study.” Environmental Health Perspectives 122 (6): 566-572. doi:10.1289/ehp.1206458. http://dx.doi.org/10.1289/ehp.1206458.
Full Text & Related Files:
Abstract: Background: Few studies have been performed on pulmonary effects of air pollution in the elderly—a vulnerable population with low reserve capacity—and mechanisms and susceptibility factors for potential effects are unclear. Objectives: We evaluated the lag structure of air pollutant associations with lung function and potential effect modification by DNA methylation (< or ≥ median) at 26 individual CpG sites in nine candidate genes in a well-characterized cohort of elderly men. Methods: We measured forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), and blood DNA methylation one to four times between 1999 and 2009 in 776 men from the Normative Aging Study. Air pollution was measured at fixed monitors 4 hr to 28 days before lung function tests. We used linear mixed-effects models to estimate the main effects of air pollutants and effect modification by DNA methylation. Results: An interquartile range (IQR) increase in subchronic exposure (3 to 28 days cumulated), but not in acute exposure (during the previous 4 hr, or the current or previous day), to black carbon, total and nontraffic particles with aerodynamic diameter ≤ 2.5 μm (PM2.5), carbon monoxide, and nitrogen dioxide was associated with a 1–5% decrease in FVC and FEV1 (p < 0.05). Slope estimates were greater for FVC than FEV1, and increased with cumulative exposure. The estimates slopes for air pollutants (28 days cumulated) were higher in participants with low (< median) methylation in TLR2 at position 2 and position 5 and high (≥ median) methylation in GCR. Conclusions: Subchronic exposure to traffic-related pollutants was associated with significantly reduced lung function in the elderly; nontraffic pollutants (particles, ozone) had weaker associations. Epigenetic mechanisms related to inflammation and immunity may influence these associations. Citation: Lepeule J, Bind MAC, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. 2014. Epigenetic influences on associations between air pollutants and lung function in elderly men: the Normative Aging Study. Environ Health Perspect 122:566–572; http://dx.doi.org/10.1289/ehp.1206458
Published Version: doi:10.1289/ehp.1206458
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050500/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406551
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters