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dc.contributor.authorTurcotte-Tremblay, Anne-Marieen_US
dc.contributor.authorLim, Roberten_US
dc.contributor.authorLaplante, David P.en_US
dc.contributor.authorKobzik, Lesteren_US
dc.contributor.authorBrunet, Alainen_US
dc.contributor.authorKing, Suzanneen_US
dc.date.accessioned2014-07-07T17:02:28Z
dc.date.issued2014en_US
dc.identifier.citationTurcotte-Tremblay, Anne-Marie, Robert Lim, David P. Laplante, Lester Kobzik, Alain Brunet, and Suzanne King. 2014. “Prenatal Maternal Stress Predicts Childhood Asthma in Girls: Project Ice Storm.” BioMed Research International 2014 (1): 201717. doi:10.1155/2014/201717. http://dx.doi.org/10.1155/2014/201717.en
dc.identifier.issn2314-6133en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406623
dc.description.abstractLittle is known about how prenatal maternal stress (PNMS) influences risks of asthma in humans. In this small study, we sought to determine whether disaster-related PNMS would predict asthma risk in children. In June 1998, we assessed severity of objective hardship and subjective distress in women pregnant during the January 1998 Quebec Ice Storm. Lifetime asthma symptoms, diagnoses, and corticosteroid utilization were assessed when the children were 12 years old (N = 68). No effects of objective hardship or timing of the exposure were found. However, we found that, in girls only, higher levels of prenatal maternal subjective distress predicted greater lifetime risk of wheezing (OR = 1.11; 90% CI = 1.01–1.23), doctor-diagnosed asthma (OR = 1.09; 90% CI = 1.00–1.19), and lifetime utilization of corticosteroids (OR = 1.12; 90% CI = 1.01–1.25). Other perinatal and current maternal life events were also associated with asthma outcomes. Findings suggest that stress during pregnancy opens a window for fetal programming of immune functioning. A sex-based approach may be useful to examine how prenatal and postnatal environments combine to program the immune system. This small study needs to be replicated with a larger, more representative sample.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2014/201717en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034394/pdf/en
dash.licenseLAAen_US
dc.titlePrenatal Maternal Stress Predicts Childhood Asthma in Girls: Project Ice Stormen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBioMed Research Internationalen
dc.date.available2014-07-07T17:02:28Z
dc.identifier.doi10.1155/2014/201717*


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